{"id":1074,"date":"2020-06-05T19:33:57","date_gmt":"2020-06-05T10:33:57","guid":{"rendered":"https:\/\/okawa-obgyn.com\/takasago\/?page_id=1074"},"modified":"2024-03-11T23:49:54","modified_gmt":"2024-03-11T14:49:54","slug":"%e8%83%9a%ef%bc%88%e5%8f%97%e7%b2%be%e5%8d%b5%ef%bc%89%e3%81%ae%e9%81%b8%e5%88%a5%e3%81%a8%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be%e3%81%ae%e5%8b%95%e5%90%91","status":"publish","type":"page","link":"https:\/\/okawa-obgyn.com\/takasago\/beginner\/%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be-ivf%e3%83%bb%e9%a1%95%e5%be%ae%e6%8e%88%e7%b2%be-icsi\/%e8%83%9a%ef%bc%88%e5%8f%97%e7%b2%be%e5%8d%b5%ef%bc%89%e3%81%ae%e9%81%b8%e5%88%a5%e3%81%a8%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be%e3%81%ae%e5%8b%95%e5%90%91\/","title":{"rendered":"\u4f53\u5916\u53d7\u7cbe\u2461 \u80da(\u53d7\u7cbe\u5375)\u9078\u5225\u3068\u4f53\u5916\u53d7\u7cbe\u306e\u52d5\u5411"},"content":{"rendered":"\n<p style=\"text-align: right;\"><br \/><a href=\"https:\/\/okawa-obgyn.com\/takasago\/beginner\/%e5%a5%b3%e6%80%a7%e5%b9%b4%e9%bd%a2%e3%81%a8%e5%8d%b5%e5%b7%a3%e4%ba%88%e5%82%99%e8%83%bd\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u2460\u5973\u6027\u5e74\u9f62\u306b\u3088\u308b\u598a\u5b55\u529b\u306e\u5909\u5316\u3000\uff08\u5375\u5de3\u4e88\u5099\u80fd\u2460\uff09<\/a><br \/><a href=\"https:\/\/okawa-obgyn.com\/takasago\/%e4%b8%8d%e5%a6%8a%e7%97%87%e3%81%ae%e5%8e%9f%e5%9b%a0%e6%a4%9c%e6%9f%bb%e3%81%a8%e6%b2%bb%e7%99%82__trashed\/%e4%b8%8d%e5%a6%8a%e7%97%87%e3%81%ae%e6%a4%9c%e6%9f%bb\/%e5%8d%b5%e5%ad%90%e3%81%ae%e7%94%9f%e6%b6%af%e7%99%ba%e8%82%b2%e3%81%a8fsh-amh-afc-%e3%81%ae%e5%bd%b9%e5%89%b2\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u2461\u5375\u5b50\u306e\u751f\u6daf\u767a\u80b2\u3068FSH, AMH, AFC \u306e\u5f79\u5272\uff08\u5375\u5de3\u4e88\u5099\u80fd\u2461\uff09<\/a><br \/><a href=\"https:\/\/okawa-obgyn.com\/takasago\/beginner\/%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be-ivf%e3%83%bb%e9%a1%95%e5%be%ae%e6%8e%88%e7%b2%be-icsi\/%e8%83%9a%ef%bc%88%e5%8f%97%e7%b2%be%e5%8d%b5%ef%bc%89%e3%81%ae%e9%81%b8%e5%88%a5%e3%81%a8%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be%e3%81%ae%e5%8b%95%e5%90%91\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u2462\u4f53\u5916\u53d7\u7cbe\u306e\u52d5\u5411\uff5e\u80da\u306e\u9078\u5225\u3068\u79fb\u690d\u306e\u598a\u5a20\u7387\uff08\u5927\u5dddART\u306e\u598a\u5a20\u7387\uff09<\/a><br \/><span style=\"font-size: 12pt;\"><strong><span style=\"color: #666699;\">\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad9\u7802\uff08\u5927\u5dddART)\u539f\u8457\u00a0 \u3000\u3000\u3000<\/span><\/strong><\/span><span style=\"font-size: 12pt;\"><strong><span style=\"color: #666699;\"><span style=\"color: #008000;\"><a style=\"color: #008000;\" href=\"https:\/\/okawa-obgyn.com\/hosp\/about\/message\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u6587\u8cac \u540d\u8a89\u9662\u9577 \u5927\u5ddd\u6b23\u6804<\/a><\/span><\/span><\/strong><\/span><\/p>\n\n\n\n<p><span style=\"font-size: 24pt;\"><span style=\"color: #333300;\"><strong><span style=\"font-size: 18pt;\">\u4f53\u5916\u53d7\u7cbe\u306e\u52d5\u5411\uff5e\u80da\u306e\u9078\u5225\u3068\u79fb\u690d\u306e\u598a\u5a20\u7387\uff08\u7dcf\u8aac\uff09<\/span><\/strong><\/span><br><\/span><span style=\"font-size: 10pt;\">\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u30a2\u30eb\u30e1\u30a4\u30c0\u533b\u5831, 2020; Vol. 45, No. 1, 2-17 \u306b\u63b2\u8f09<\/span><\/p>\n\n\n\n<div id=\"toc_container\" class=\"no_bullets\"><ul class=\"toc_list\"><li><a href=\"#i\"><span class=\"toc_number toc_depth_1\">1<\/span> \u8981 \u65e8<\/a><\/li><li><a href=\"#i-2\"><span class=\"toc_number toc_depth_1\">2<\/span> \u65e5\u672c\u306b\u304a\u3051\u308b\u4f53\u5916\u53d7\u7cbe\u8fd1\u5e74\u306e\u52d5\u5411<\/a><ul><li><a href=\"#i-3\"><span class=\"toc_number toc_depth_2\">2.1<\/span> \u65b0\u9bae\u80da\u79fb\u690d\u3088\u308a\u51cd\u7d50\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u304c\u9ad8\u3044\u7406\u7531<\/a><\/li><li><a href=\"#i-4\"><span class=\"toc_number toc_depth_2\">2.2<\/span> \u521d\u671f(\u5206\u5272)\u80da\u3088\u308a\u80da\u76e4\u80de\u79fb\u690d\u306e\u598a\u5a20\u7387\u304b\u9ad8\u3044\u7406\u7531<\/a><\/li><\/ul><\/li><li><a href=\"#In_vivo_in_vitro\"><span class=\"toc_number toc_depth_1\">3<\/span> \u4f53\u5185(In vivo)\u3068\u4f53\u5916( in vitro )\u306b\u304a\u3051\u308b\u53d7\u7cbe\u5375\u306e\u767a\u80b2\u904e\u7a0b<\/a><ul><li><a href=\"#i-5\"><span class=\"toc_number toc_depth_2\">3.1<\/span> \u4f53\u5916\u53d7\u7cbe\u6642\u306b\u304a\u3051\u308b\u53d7\u7cbe\u5375\u306e\u767a\u80b2\uff0d\u521d\u671f\u80da\u306e\u8a55\u4fa1\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/a><\/li><li><a href=\"#ART5\"><span class=\"toc_number toc_depth_2\">3.2<\/span> \u53d7\u7cbe\uff13\u65e5\u76ee\u5206\u5272\u80da\u306e\u7d30\u80de\u6570\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f3\uff15\uff09<\/a><\/li><\/ul><\/li><li><a href=\"#i-6\"><span class=\"toc_number toc_depth_1\">4<\/span> \u80da\u76e4\u80de\u306e\u8a55\u4fa1\u6cd5\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/a><ul><li><a href=\"#ICMTEES\"><span class=\"toc_number toc_depth_2\">4.1<\/span> \u80da\u76e4\u80de\u306eICM\u3068TE\u7d30\u80de\u306e\u5206\u5316\u3068ES\u7d30\u80de<\/a><\/li><li><a href=\"#_ES_cells_Embryonic_stem_cells\"><span class=\"toc_number toc_depth_2\">4.2<\/span> \u80da\u6027\u5e79\u7d30\u80de ES cells (Embryonic stem cells)<\/a><\/li><li><a href=\"#Gardner\"><span class=\"toc_number toc_depth_2\">4.3<\/span> \u80da\u76e4\u80de\u306e\u8a55\u4fa1\u6cd5\u30fbGardner \u5206\u985e<\/a><\/li><\/ul><\/li><li><a href=\"#Day56\"><span class=\"toc_number toc_depth_1\">5<\/span> \u80da\u76e4\u80de(Day5,6)\u5f62\u614b\u7684\u8a55\u4fa1\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/a><ul><li><a href=\"#StageART5\"><span class=\"toc_number toc_depth_2\">5.1<\/span> \u80de\u80da\u8154\u62e1\u5f35Stage\u5225\u81e8\u5e8a\u598a\u5a20\u7387\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f3\uff19\uff09<\/a><\/li><li><a href=\"#ICMTE_GradeART5-10\"><span class=\"toc_number toc_depth_2\">5.2<\/span> \u5185\u7d30\u80de\u584aICM\/\u6804\u990a\u5916\u80da\u8449TE Grade\u5225\u81e8\u5e8a\u598a\u5a20\u7387\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f310\uff09<\/a><\/li><\/ul><\/li><li><a href=\"#i-7\"><span class=\"toc_number toc_depth_1\">6<\/span> \u8003 \u5bdf<\/a><ul><li><a href=\"#i-8\"><span class=\"toc_number toc_depth_2\">6.1<\/span> \u5973\u6027\u306e\u5e74\u9f62\u3068\u80da\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027<\/a><\/li><li><a href=\"#i-9\"><span class=\"toc_number toc_depth_2\">6.2<\/span> \u80da\u76e4\u80de\u306e\u80de\u80da\u8154\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u7570\u6570\u6027<\/a><\/li><li><a href=\"#i-10\"><span class=\"toc_number toc_depth_2\">6.3<\/span> \u80da\u306e\u9078\u5225\u8981\u4ef6<\/a><\/li><\/ul><\/li><li><a href=\"#i-11\"><span class=\"toc_number toc_depth_1\">7<\/span> \u82f1\u6587\u7dcf\u62ec<\/a><\/li><\/ul><\/div>\n<h2 class=\"wp-block-heading\"><span id=\"i\"><strong>\u8981 \u65e8<\/strong><\/span><\/h2>\n\n\n\n<p>\u3000\uff12\uff10\uff119\u5e74\u3001\u30a2\u30eb\u30e1\u30a4\u30c0\u533b\u5831\u306b\u63b2\u8f09\u3057\u305f\u300c\u5973\u6027\u5e74\u9f62\u306b\u3088\u308b\u598a\u5b55\u529b\u306e\u5909\u5316\u300d1\uff09\u306b\u30662018 \u5e74\u306e\u5168\u56fd\u51fa\u751f\u6570\u306f91\u4e078\u53434\u767e\u4eba\u3068\uff13\u5e74\u9023\u7d9a\u3067\u904e\u53bb\u6700\u4f4e\u6570\u3092\u66f4\u65b0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8ff0\u3079\u305f\u304c\u30012019\u5e74\u306e\u51fa\u751f\u6570\u306f\u521d\u3081\u3066\u306e90\u4e07\u4eba\u5272\u308c\u306e86\u4e074\u5343\u4eba\u3067\u3042\u308a\u3001\u66f4\u306b\u5c11\u5b50\u5316\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>\u3000\u5c11\u5b50\u5316\u306e\u8981\u56e0\u306f\u3001\u6319\u5150\u3092\u5e0c\u671b\u3059\u308b\u5973\u6027\u306e\u6e1b\u5c11\u306e\u307f\u306a\u3089\u305a\u3001\u598a\u5a20\u51fa\u7523\u306e\u9ad8\u9f62\u5316\u306b\u3088\u308b\u5375\u5de3\u4e88\u5099\u80fd\uff08Ovarian reserve\uff092\uff09\u306e\u4f4e\u4e0b\u3084\u67d3\u8272\u4f53\u7570\u5e38\u306e\u5897\u52a0\u306a\u3069\u306b\u3088\u308b\u598a\u5b55\u529b\u306e\u4f4e\u4e0b\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u4e0d\u598a\u75c7\u306b\u60a9\u3093\u3067\u3044\u308b\u30ab\u30c3\u30d7\u30eb\u306f\u5e74\u3005\u5897\u52a0\u3057\u30015\uff5e6\u7d44\u306b1\u7d44\u3068\u3082\u8a00\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u3000\u4e0d\u598a\u75c7\u306b\u6700\u3082\u6709\u529b\u306a\u6cbb\u7642\u306f\u4f53\u5916\u53d7\u7cbe\uff08ART) \u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002 2017\u5e74\u3001\u65e5\u672c\u306e\u4e0d\u598a\u6cbb\u7642\u65bd\u8a2d\u3067\u306eART\u306e\u6cbb\u7642\u5468\u671f\u306f448,210\u4ef6\u3001\u79fb\u690d\u5468\u671f\u6570\u306f251,279\u4ef6\u3001\u598a\u5a20\u5468\u671f\u6570\u306f79,194\u4ef6\u3001\u751f\u7523\u5468\u671f\u6570\u306f54,997\u4ef6\u3001\u751f\u5150\u6570\u306f56,617\u4eba\u3067\u3042\u308b\u30022017\u5e74\u306e\u51fa\u751f\u6570\u306f94\u4e076060\u4eba\u3067\u3001\u7d0416.7\u4eba\u306b\uff11\u4eba\u306fART Baby\u3067\u3042\u308a\u300140\u4eba\u306e\u5b66\u7d1a\u306b\uff12.4\u4eba\u306e\u5b50\u4f9b\u306fART Baby\u3067\u3042\u308b\u3002\uff13\uff09<\/p>\n<p>\u3000\u8fd1\u5e74\u3001\u7279\u306b\u65e5\u672c\u306b\u304a\u3051\u308bART\u306e\u7279\u5fb4\u306f\u9ad8\u9f62\u8005\u306e\u5272\u5408\u304c\u591a\u3044\uff0840\u6b73\u4ee5\u4e0a\u306f42\uff05\uff09\u3001\u51cd\u7d50\u79fb\u690d\u5468\u671f\u304c\u591a\u3044\uff08\u7d0480\uff05\uff09\u3001\u5358\u4e00\u80da\u79fb\u690d\u306e\u5272\u5408\u304c\u591a\u3044\uff08\u6210\u679c\u3068\u3057\u3066\u306f\u591a\u80ce\u7387\u304c3\uff05\u3068\u4f4e\u3044\uff09\u3001\u80da\u76e4\u80de\u79fb\u690d\u306e\u5272\u5408\u304c\u9ad8\u3044\u3053\u3068\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001\u65e5\u672c\u306eART\u306e\u65bd\u884c\u5468\u671f\u6570\u306f42\u4e07\u5468\u671f\u3068\u4e16\u754c\u5404\u56fd\u3068\u6bd4\u3079\u3001\u6700\u591a\uff08\u4e2d\u56fd\u306f\u672a\u7d71\u8a08\uff09\u3067\u3042\u308b\u304c\u3001\u9ad8\u9f62\u8005\u306e\u5272\u5408\u304c\u9ad8\u304f\u3001\u793e\u4f1a\u7684\u9069\u5fdc\u5375\u5b50\u51cd\u7d50\u306f\u5c11\u306a\u3044\u3002\u66f4\u306b\u5375\u5b50\u63d0\u4f9b\u306b\u3088\u308bART\u3068\u7740\u5e8a\u524d\u67d3\u8272\u4f53\u691c\u67fb\u306f\u3001\u65e5\u672c\u3067\u306f\u516c\u8a8d\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u4f53\u5916\u53d7\u7cbe\u3084\u9855\u5fae\u6388\u7cbe\u306a\u3069\u306e\u751f\u6b96\u88dc\u52a9\u533b\u7642\u306e\u6210\u7e3e\u306f\u4f9d\u7136\u3068\u53b3\u3057\u3044\u72b6\u614b\u3068\u8a00\u3048\u308b\u3002\u4f8b\u3048\u307035\u6b73\u304b\u3089\u6319\u5150\u306e\u78ba\u7387\u306f20\uff05\uff08\u751f\u7523\u7387\uff0f\u7dcf\u6cbb\u7642\u56de\u6570\uff09\u3092\u5207\u308b\u300140\u6b73\u304b\u308910\uff05\u4ee5\u4e0b\u306b\u306a\u308a\u3001\u6d41\u7523\u7387\u308240\u6b73\u4ee5\u5f8c\u306b\u6025\u901f\u306b\u5897\u52a0\u3059\u308b\u50be\u5411\u306b\u3042\u308b\u3002\uff13\uff09<\/p>\n<p>\u3000\u4f53\u5916\u53d7\u7cbe\u306b\u304a\u3044\u3066\u53d7\u7cbe\u5375\u306e\u57f9\u990a\u904e\u7a0b\u3068\u79fb\u690d\u80da\u306e\u9078\u5225\u306f\u3001\u6cbb\u7642\u6210\u7e3e\u306b\u304b\u304b\u308f\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u3002\u5e74\u9f62\u3068\u5375\u5de3\u4e88\u5099\u80fd\uff08AMH, FSH\u5024\u3084AFC\u306a\u3069\uff09\u306b\u3088\u308a\u3001\u63a1\u5375\u6570\u3001\u53d7\u7cbe\u7387\u3001\u80da\u306e\u767a\u80b2\u306f\u305d\u308c\u305e\u308c\u5927\u304d\u3044\u306a\u9055\u3044\u304c\u898b\u3089\u308c\u308b\u30022\uff09\u63a1\u5375\u3084\u53d7\u7cbe\u80da\u306e\u7372\u5f97\u304c\u4e0d\u53ef\u80fd\u306a\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u306f\u3001\u4eca\u306e\u3068\u3053\u308d\u5375\u5b50\u63d0\u4f9b\u4ee5\u5916\u306b\u6709\u52b9\u306a\u5bfe\u51e6\u6cd5\u304c\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3042\u308b\u3002\u521d\u671f\u5206\u5272\u80da\u307e\u3067\u5f97\u3089\u308c\u3066\u3082\u80da\u306e\u8cea\u304c\u4e0d\u5341\u5206\u306a\u305f\u3081\u80da\u76e4\u80de\u307e\u3067\u306e\u9577\u671f\u57f9\u990a\u3092\u907f\u3051\u308b\u5834\u5408\u306fVeeck\u5206\u985e\u6cd5\u3092\u7528\u3044\u3066\u79fb\u690d\u80da\u306e\u9078\u5225\u3092\u884c\u3046\u3002\u53d7\u7cbe\u5375\u3092\u591a\u304f\u7372\u5f97\u3057\u3001\u9577\u671f\u57f9\u990a\u306b\u3088\u308a\u8907\u6570\u306e\u80da\u76e4\u80de\u304c\u5f97\u3089\u308c\u308b\u5834\u5408\u3001\u79fb\u690d\u80da\u306e\u9078\u629e\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u80da\u76e4\u80de\u8a55\u4fa1\u6cd5\u306fGardner\u5206\u985e\u6cd5\u3067\u3042\u308b\u3002<br><strong>\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802\u30672014\u5e74\u304b\u30892018\u5e74\u307e\u3067\u306e5\u5e74\u9593\u306b\u884c\u3063\u305f\u3001Veeck\u5206\u985e\u6cd5\u3067\u80da\u306e\u8a55\u4fa1\u30fb\u79fb\u690d\u3092\u884c\u3063\u305f\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u5206\u5272\u80da\u79fb\u690d428\u5468\u671f\u3001Gardner\u5206\u985e\u6cd5\u3067\u80da\u306e\u8a55\u4fa1\u30fb\u79fb\u690d\u3092\u884c\u3063\u305f\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80de\u79fb\u690d654\u5468\u671f\u3088\u308a\u3001\u305d\u306e\u6210\u7e3e\u3092\u7d71\u8a08\u5b66\u7684\u306b\u691c\u8a0e\u3057\u305f\u3002\u56f3\uff15,\u56f3\uff19\uff64\u56f310<\/strong> \u307e\u305f\u3001\u79fb\u690d\u80da\u306e\u5f62\u614b\u7684\u3001\u52d5\u614b\u7684\u8a55\u4fa1\u3068\u67d3\u8272\u4f53\u7570\u6570\u6027\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u6587\u732e\u7684\u306b\u8003\u5bdf\u3057\u305f\u3002<\/p>\n\n\n<h2><span id=\"i-2\">\u65e5\u672c\u306b\u304a\u3051\u308b\u4f53\u5916\u53d7\u7cbe\u8fd1\u5e74\u306e\u52d5\u5411<\/span><\/h2>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"607\" class=\"wp-image-1079\" alt=\"\" src=\"\/takasago\/images\/2020\/06\/\u56f31\u30002017\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387-1024x607.jpg\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f31\u30002017\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387-1024x607.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f31\u30002017\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387-300x178.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f31\u30002017\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387-768x455.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f31\u30002017\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387.jpg 1049w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\n<figcaption><strong>\u5e74\u5225\u3000\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387 &nbsp; &nbsp; &nbsp; * 2007\u5e74\u4ee5\u964d\u306f\u5168\u80da\u51cd\u7d50\u5468\u671f\u3092\u9664\u3044\u3066\u8868\u793a<br><br>\u56f3\uff11\uff0e1989\u5e74\uff5e2017\u5e74\u5168\u56fd\u4f53\u5916\u53d7\u7cbe\u306e\u52d5\u5411\u2015\u598a\u5a20\u7387\u30fb\u751f\u7523\u7387\u30fb\u591a\u80ce\u7387\u306e\u5e74\u5225\u63a8\u79fb<br>\u65e5\u672c\u7523\u79d1\u5a66\u4eba\u79d1\u5b66\u4f1a \u502b\u7406\u59d4\u54e1\u4f1a \u767b\u9332\u30fb\u8abf\u67fb\u5c0f\u59d4\u54e1\u4f1a \u5e73\u621030\u5e74\u5ea6\u5831\u544a: 2017\u5e74\u5206\u306e\u4f53\u5916\u53d7\u7cbe\u30fb\u80da\u79fb\u690d\u7b49\u306e\u81e8\u5e8a\u5b9f\u65bd\u6210\u7e3e\uff13\uff09<br><\/strong><\/figcaption>\n<\/figure>\n\n\n\n<h4>\u2460 \u591a\u80ce\u7387<\/h4>\n\n\n\n<p>\u5f93\u6765\u306e\u4f53\u5916\u53d7\u7cbe\u306f\u307b\u3068\u3093\u3069\u8907\u6570\u80da\u79fb\u690d\u3092\u884c\u3044\u3001\u591a\u80ce\u598a\u5a20\u4f8b\u306e\u5897\u52a0\u3088\u308a\u6bcd\u4f53\u30fb\u80ce\u5150\u306e\u30ea\u30b9\u30af\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u30022007\u5e74\u306b\u306f\u65e5\u672c\u751f\u6b96\u533b\u5b66\u4f1a,\u65e5\u672c\u7523\u79d1\u5a66\u4eba\u79d1\u5b66\u4f1a\u304c\u300c\u591a\u80ce\u598a\u5a20\u9632\u6b62\u306e\u305f\u3081\u306e\u79fb\u690d\u80da\u6570\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300d\u3092\u7b56\u5b9a\u3057\u3001\u5358\u4e00\u80da\u79fb\u690d\uff08SET, Single Embryo Transfer\uff09\u3092\u63a8\u5968\u3057\u305f\u3053\u3068\u306b\u3088\u308a\u3001\u591a\u80ce\u7387\u306f2000\u5e74\u524d\u5f8c\u306e15\uff05\u304b\u3089\u73fe\u5728\u306e\uff13\uff05\u307e\u3067\u4f4e\u4e0b\u3057\u3001\u65e5\u672c\u306f\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u3068\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3068\u4e26\u3073\u3001\u5b89\u5168\u306aART\u304c\u63d0\u4f9b\u3055\u308c\u308b\u56fd\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h4>\u2461 \u65b0\u9bae\u80da\u79fb\u690d\u3068\u51cd\u7d50\u80da\u79fb\u690d\u3000\u598a\u5a20\u7387\u306e\u6642\u4ee3\u7684\u5909\u5316<\/h4>\n\n\n\n<p>2002\u5e74\u307e\u3067\u306e\u598a\u5a20\u7387\u306f\u307b\u3068\u3093\u3069\u5909\u308f\u308a\u306a\u3044\u304c\u3001\u305d\u306e\u5f8c\u3001\u51cd\u7d50\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f\u5927\u5e45\u306b\u4e0a\u6607\u3057\u305f\u30022017\u5e74 \u65b0\u9bae\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f21.4%\uff08\u598a\u5a20\u7387\/ET\uff09\u3001\u51cd\u7d50\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f34.4% \uff08\u598a\u5a20\u7387\/ET\uff09\u3067\u3042\u308b\u30022017\u5e74\u51cd\u7d50\u80da\u79fb\u690d\u306e\u65bd\u884c\u5468\u671f\u6570(n=195,559)\u306f\u65b0\u9bae\u80da\uff08n=55,720)\u306e3.51\u500d\u306b\u306a\u308a\u3001\u51fa\u751f\u5150\u6570\u306f5.62\u500d(n=46,642\/8,355)\u306b\u9054\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u56fd\u5185\u306e\u591a\u304f\u306e\u65bd\u8a2d\u3067\u306f\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u304c\u79fb\u690d\u65b9\u6cd5\uff08\u5168\u80da\u51cd\u7d50, Freeze-All)\u306e\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3068\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"> \u2462 \u751f\u7523\u7387\uff08\/\u63a1\u5375\uff09 <\/h4>\n\n\n\n<p>\u63a1\u5375\u306b\u5bfe\u3059\u308b\u598a\u5a20\u7387\u306f2004\u5e74\u304b\u30892017\u5e74\u307e\u3067\u5e74\u3005\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u305d\u308c\u306f\u5973\u6027\u306e\u5e73\u5747\u521d\u5a5a\u5e74\u9f62\u306e\u4e0a\u6607\u30571\uff09\u3001ART\u6cbb\u7642\u306e\u4e3b\u8981\u5e74\u9f62\u5c64\u30822004\u5e74\u306e35\uff5e36\u6b73\u304b\u30892017\u5e74\u306e40\uff5e41\u6b732\uff09\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3088\u308a\u3001\u9ad8\u9f62\u306b\u3088\u308b\u80da\u306e\u67d3\u8272\u4f53\u7570\u5e38\u3068\u96e3\u6cbb\u6027\u4e0d\u598a\u75c7\u306e\u5897\u52a0\u304c\u751f\u7523\u7387\uff08\/\u63a1\u5375\uff09\u6e1b\u5c11\u306e\u4e00\u5927\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u56f3\uff11<\/p>\n\n\n\n<h3><span id=\"i-3\">\u65b0\u9bae\u80da\u79fb\u690d\u3088\u308a\u51cd\u7d50\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u304c\u9ad8\u3044\u7406\u7531<\/span><\/h3>\n\n\n<p>\u2776 \u5375\u5de3\u523a\u6fc0\u5468\u671f\u306e\u65b0\u9bae\u80da\u79fb\u690d\u3067\u306f\u598a\u5a20\u6210\u7acb\u6642\u306b\u5375\u5de3\u904e\u5270\u523a\u6fc0\u75c7\u5019\u7fa4\uff08OHSS\uff09\u3092\u767a\u75c7\u3001\u91cd\u75c7\u5316\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u306e\u3067\u3001\u614e\u91cd\u306b\u304a\u3053\u306a\u3046\u3079\u304d\u3067\u3042\u308b\u3002\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u306f\u65b0\u9bae\u80da\u79fb\u690d\u306b\u6bd4\u3079\u3001OHSS\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u304f\u306a\u308a\u3001\u6708\u7d4c\u3092\u8de8\u3050\u305f\u3081\u3001\u5b50\u5bae\u5185\u819c\u74b0\u5883\u3068\u30db\u30eb\u30e2\u30f3\u306e\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u7740\u5e8a\u3057\u3084\u3059\u304f\u3001\u6d41\u7523\u7387\u304c\u4f4e\u3044\u50be\u5411\u306b\u3042\u308b\u3002<\/p>\n<p>\u2777 \u63a1\u5375\u5f8c\u305d\u306e\u307e\u307e\u80da\u79fb\u690d\u3059\u308b\u65b0\u9bae\u80da\u79fb\u690d\u306e\u5834\u5408\u306f\u3001\u9ad8\u523a\u6fc0\u6cd5\u306b\u3088\u308a\u591a\u6570\u306e\u5375\u80de\u767a\u80b2\u304b\u3089P4\u306e\u7570\u5e38\u4e0a\u6607\u304c\u898b\u3089\u308c\u3001\u5b50\u5bae\u5185\u819c\u306e\u7740\u5e8a\u6e96\u5099\u304c\u305a\u308c\u3066\u3001Implantation window\uff08\u7740\u5e8a\u306e\u7a93\uff09\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u304c\u3061\u3067\u3042\u3063\u305f\u3002\u305d\u308c\u306f\u65b0\u9bae\u80da\u79fb\u690d\u304c\u7740\u5e8a\u3057\u96e3\u3044\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u3067\u306f\u3001implantation window\u306b\u5408\u308f\u305b\u3084\u3059\u3044\u306e\u3067\u3001\u6bd4\u8f03\u9ad8\u3044\u598a\u5a20\u7387\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u8fd1\u5e74ERA\u691c\u67fb (Endometrial Receptivity Analysis)\u304c\u958b\u767a\u3055\u308c\u3066\u3001\u5b50\u5bae\u5185\u819c\u7d44\u7e54\u306e\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3092\u8abf\u3079\u3066\u3001\u7740\u5e8a\u53ef\u80fd\u306a\u72b6\u614b\u306b\u6574\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u65b9\u6cd5\u3082\u3042\u308b\u3002<\/p>\n<p>\u2778 2000\u5e74\u3088\u308a\u51cd\u7d50\u30fb\u878d\u89e3\u6280\u8853\u306e\u5411\u4e0a\u306b\u3088\u308a\u3001\u51cd\u7d50\u878d\u89e3\u80da\u306e\u56de\u5fa9\u72b6\u614b\u304c\u6539\u5584\u3055\u308c\u598a\u5a20\u7387\u304c\u4e0a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u4e00\u822c\u7684\u306a\u81e8\u5e8a\u73fe\u5834\u306b\u304a\u3044\u3066\u51cd\u7d50\u80da\u3092\u9078\u629e\u3059\u308b\u969b\u306b\u3001\u51cd\u7d50\u3068\u89e3\u51cd\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u8010\u3048\u3089\u308c\u308b\u5f62\u614b\u7684\u826f\u597d\u80da\u3001Veeck\u5206\u985e\u3084Gardner\u5206\u985e\u306b\u8a55\u4fa1\u306e\u9ad8\u3044\u80da\u3092\u512a\u5148\u3057\u3066\u9078\u629e\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u7d50\u679c\u3001\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f2003\u5e74\u3088\u308a\u5e74\u3005\u3068\u9ad8\u304f\u306a\u308b\u3002\u9006\u306b\u3001\u826f\u597d\u80da\u3068\u3057\u3066\u9078\u629e\u3055\u308c\u306a\u304b\u3063\u305f\u80da\u304c\u65b0\u9bae\u80da\u79fb\u690d\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u65b0\u9bae\u80da\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f\u5e74\u3005\u3068\u4f4e\u304f\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u56f3\uff11\u3000\u9078\u5225\u304b\u3089\u9664\u5916\u3055\u308c\u305f\u80da\u306b\u3082\u598a\u5a20\u306e\u53ef\u80fd\u6027\u306f\u3042\u308b\u305f\u3081\u3001\u65b0\u9bae\u80da\u79fb\u690d\u304c\u3001\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u306b\u5168\u9762\u7684\u306b\u52a3\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u3002<\/p>\n\n\n<h4 class=\"wp-block-heading\"><strong>2017\u5e74\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387\u306e\u5909\u5316<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"\/takasago\/images\/2020\/06\/\u56f32\u30002017\u5e74-\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387.jpg\" alt=\"\" class=\"wp-image-1080\" width=\"625\" height=\"463\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f32\u30002017\u5e74-\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387.jpg 788w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f32\u30002017\u5e74-\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387-300x222.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f32\u30002017\u5e74-\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387-768x569.jpg 768w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><figcaption> <strong>\u56f3\uff12<\/strong>\uff0e<a>2017\u5e74 \u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u5225\u30fb\u5e74\u9f62\u5225\u306e\u79fb\u690d\u3042\u305f\u308a\u598a\u5a20\u7387<\/a><br> \u65e5\u672c\u7523\u79d1\u5a66\u4eba\u79d1\u5b66\u4f1a \u502b\u7406\u59d4\u54e1\u4f1a \u767b\u9332\u30fb\u8abf\u67fb\u5c0f\u59d4\u54e1\u4f1a \u5e73\u621030\u5e74\u5ea6\u5831\u544a: 2017\u5e74\u5206\u306e\u4f53\u5916\u53d7\u7cbe\u30fb\u80da\u79fb\u690d\u7b49\u306e\u81e8\u5e8a\u5b9f\u65bd\u6210\u7e3e\uff13<strong>\uff09<\/strong><\/figcaption><\/figure>\n\n\n<p>\u2460 \u3059\u3079\u3066\u306e\u79fb\u690d\u30b9\u30c6\u30fc\u30b8\u306e\u598a\u5a20\u7387\u306f\u5e74\u9f62\u3068\u5171\u306b\u4f4e\u4e0b\u3059\u308b\u3002<br>\u2461 \u51cd\u7d50\u80da\u76e4\u80de \u3068\u65b0\u9bae\u80da\u76e4\u80de \u306e\u79fb\u690d\u306f\u3001\u5404\u5e74\u9f62\u5c64\u306b\u304a\u3044\u3066\u3001\u51cd\u7d50\u521d\u671f\u80da \u306f\u65b0\u9bae\u521d\u671f\u80da \u3088\u308a\u660e\u3089\u304b\u306b\u9ad8\u3044\u598a\u5a20\u7387\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n<h3><span id=\"i-4\"><a id=\"earlyembryo\"><\/a>\u521d\u671f(\u5206\u5272)\u80da\u3088\u308a\u80da\u76e4\u80de\u79fb\u690d\u306e\u598a\u5a20\u7387\u304b\u9ad8\u3044\u7406\u7531<\/span><\/h3>\n\n\n<p>\u63a1\u5375\u5f8c\u57f9\u990a2\uff5e3\u65e5\u76ee\u306e\u521d\u671f\u80da\u306b\u6bd4\u3079\u3001\u63a1\u5375\u5f8c\u57f9\u990a5\uff5e6\u65e5\u76ee\u306e\u80da\u76e4\u80de\u306e\u7740\u5e8a\u7387\u304c\u5404\u5e74\u9f62\u5c64\u306b\u304a\u3044\u3066\u3001\u660e\u3089\u304b\u306b\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002 Gaurav\u30892017\u5e74\u306e\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u521d\u671f\u80da\uff08cleavage stage)\u306e\u67d3\u8272\u4f53\u6b63\u500d\u6570\u306e\u78ba\u7387\u306f\uff08\u5f62\u614b\u826f\u597d\u80da : 40.6% , \u5f62\u614b\u4e2d\u7b49\u80da : 29.3% , \u5f62\u614b\u4e0d\u826f\u80da\uff1a25.8%) \u306b\u5bfe\u3057\u3066\u80da\u76e4\u80de\u306e\u6b63\u500d\u6570\u306e\u78ba\u7387\uff08\u5f62\u614b\u826f\u597d\u80da : 73.2% , \u5f62\u614b\u4e2d\u7b49\u80da : 50.0% , \u5f62\u614b\u4e0d\u826f\u80da\uff1a40.5%) \u304c\u9ad8\u304f\u3001\u7d50\u679c\u3068\u3057\u3066\u598a\u5a20\u7387\u306f\u9ad8\u304f\u3001\u6d41\u7523\u7387\u306f\u4f4e\u304f\u3001\u51fa\u7523\u7387\u306f\u9ad8\u304f\u3001\u5150\u306e\u7570\u5e38\u7387\u306f\u4f4e\u3044\u3053\u3068\u306b\u306a\u308b\u30024\uff09\u598a\u5a20\u7387\u304c\u671f\u5f85\u3067\u304d\u308b\u80da\u76e4\u80de\u79fb\u690d\u3067\u306f\u5358\u4e00\u80da\u79fb\u690d\u3092\u9078\u629e\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u591a\u80ce\u598a\u5a20\u306e\u9632\u6b62\u306b\u3082\u3064\u306a\u304c\u308b\u3002<\/p>\n<p>\u80da\u76e4\u80de\u306e\u57f9\u990a\u3067\u306f\u3001\u4e00\u822c\u7684\u306b\u306f\u53d7\u7cbe\u5375\/\u80da\u57f9\u990a\u306e\u6d41\u308c\u306e\u4e2d\u306bDay2,3\u306e\u5206\u5272\u80da\/\u521d\u671f\u80da\u3092\u5f62\u614b\u7684\u306b\u826f\u3044\uff08\u767a\u80b2\u304c\u6bd4\u8f03\u7684\u65e9\u3044\uff09\u3082\u306e\u3092\u9078\u5225\u3057\u3001\u66f4\u306b\uff12\uff5e\uff13\u65e5\u9593\u3092\u8ffd\u52a0\u57f9\u990a\u3057\u3001\u6dd8\u6c70\u3055\u308c\u306a\u3044\u767a\u80b2\u9806\u8abf\u306e\u80da\u304c\u826f\u597d\u80da\u76e4\u80de\u306b\u306a\u308b\u3002\u4e00\u9023\u306e\u9078\u5225\u306e\u904e\u7a0b\u306b\u81ea\u7136\u3068\u6b63\u500d\u6570\u67d3\u8272\u4f53\u306e\u80da\u76e4\u80de\u304c\u591a\u304f\u751f\u304d\u6b8b\u308a\u3001\u598a\u5a20\u3057\u3084\u3059\u304f\u306a\u308b\u3002\u3057\u304b\u3057\u3001\u9ad8\u9f62\u3084\u5375\u5de3\u4e88\u5099\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u60a3\u8005\u3067\u306f\u3001\u6570\u7684\u3082\u3057\u304f\u306f\u5f62\u614b\u7684\u4e0d\u5341\u5206\u306a\u80da\u3057\u304b\u5f97\u3089\u308c\u306a\u3044\u5834\u5408\u304c\u591a\u3044\u306e\u3067\u3001\u5206\u5272\u80da\/\u521d\u671f\u80da\u306e\u9078\u5225\u3068\u79fb\u690d\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n<h2><span id=\"In_vivo_in_vitro\">\u4f53\u5185(In vivo)\u3068\u4f53\u5916( in vitro )\u306b\u304a\u3051\u308b\u53d7\u7cbe\u5375\u306e\u767a\u80b2\u904e\u7a0b<\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"799\" src=\"\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3-1024x799.jpg\" alt=\"\" class=\"wp-image-1081\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3-1024x799.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3-300x234.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3-768x599.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3-1536x1198.jpg 1536w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f3\uff13\u3000cleavage-and-blastocyst-formation.jpg-3.jpg 1636w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <strong>\u56f3\uff13<\/strong> <a>\u4f53\u5185\u81ea\u7136\u598a\u5a20\u6642\u3001\u53d7\u7cbe\u5375\u306e\u767a\u80b2\u904e\u7a0b (In vivo)<\/a>\u3000\uff08Fundamentals of Anatomy &amp; Physiology by <a href=\"https:\/\/www.goodreads.com\/author\/show\/1647.Frederic_H_Martini\">Frederic H. Martini<\/a> PhD \u4e00\u90e8\u6539\u7de8\uff09 <\/figcaption><\/figure>\n\n\n<p>\u6392\u5375\u3001\u53d7\u7cbe\u3057\u3066\u304b\u3089\u7d30\u80de\u5206\u88c2\u304c\u59cb\u307e\u308b\u3002\u5375\u7ba1\u5185\u3092\u901a\u904e\u4e2d\u306b1\u7d30\u80de\u21922\u7d30\u80de\u21924\u7d30\u80de\u21928\u7d30\u80de\u3068\u5206\u88c2\u3059\u308b\u3002\uff082\uff5e3\u65e5\u76ee\u306e\uff14\uff5e\uff18\u7d30\u80de\u306f\u521d\u671f\u80da\u3068\u8a00\u3046\u3002\uff09\u305d\u306e\u5f8c\u3001\u7d30\u80de\u540c\u58eb\u304c\u6eb6\u3051\u5408\u3063\u3066\u878d\u5408\u3057\u300116\uff5e32\u7d30\u80de\u306e\u6851\u5b9f\u80da\uff08Morula\uff09\u3068\u306a\u308b\u3002\u7d30\u80de\u306f\u66f4\u306b\u5206\u88c2\u3057\u3001\u6c34\u3092\u4e2d\u306b\u53d6\u308a\u8fbc\u3093\u3067\u5185\u8154\u3092\u5f62\u6210\u3057\u3001\u53d7\u7cbe\u3057\u3066\u304b\u3089\uff15\uff5e\uff16\u65e5\u76ee\u306b\u304a\u3088\u305d100\uff5e200\u500b\u306e\u7d30\u80de\u3088\u308a\u306a\u308b\u80da\u76e4\u80de\u3068\u306a\u308b\u3002\u305d\u306e\u3053\u308d\u306b\u306f\u5375\u7ba1\u3092\u901a\u3063\u3066\u5b50\u5bae\u5185\u8154\u306b\u5230\u9054\u3059\u308b\u3002<br>\u4f53\u5916\u53d7\u7cbe\u306e\u5834\u5408\u306f\u3001\u63a1\u5375\u306b\u3088\u308a\u5375\u5de3\u5185\u306e\u5375\u5b50\u3092\u4f53\u5916\u306b\u53d6\u308a\u51fa\u3057\u3066\u3001\u81ea\u7136\u53d7\u7cbe\uff08\u5a92\u7cbe\uff09\u3042\u308b\u3044\u306f\u9855\u5fae\u6388\u7cbe\u3092\u884c\u3044\u53d7\u7cbe\u3001\u4f53\u5185\u306e\u5375\u7ba1\u5185\u3068\u540c\u3058\u3088\u3046\u306b\u4f53\u5916\u306e\u57f9\u990a\u74b0\u5883\u3067 ( in vitro ) \u7d30\u80de\u5206\u88c2\u3057\u3001\uff13\u65e5\u76ee\u306e\uff18\u7d30\u80de\u524d\u5f8c\u306e\u5206\u5272\u80da\u3092\u5b50\u5bae\u5185\u8154\u306b\u79fb\u690d\u3059\u308b\u3002\u53c8\u306f\u3001\uff15\uff5e6\u65e5\u76ee\u306e\u80da\u76e4\u80de\u3092\u79fb\u690d\u3059\u308b\u3002<br>\u80da\u76e4\u80de\u304c\u6210\u9577\u3092\u7d9a\u3051\u308b\u3068\u3001\u80da\u76e4\u80de\u306e\u900f\u660e\u5e2f\u304c\u66f4\u306b\u8584\u304f\u306a\u3063\u3066\uff08\u62e1\u5f35\u80da\u76e4\u80de\uff09\u3001\u3084\u304c\u3066\u4e80\u88c2\u304c\u751f\u3058\u3001\u80da\u306f\u7834\u308c\u305f\u900f\u660e\u5e2f\u306e\u5916\u306b\u51fa\u59cb\u3081\uff08\u8131\u51fa\u80da\u76e4\u80de\uff09\u3001\u6700\u7d42\u7684\u306b\u6bbb\u306e\u5916\u306b\u5b8c\u5168\u306b\u8131\u51fa\u3057\uff08\u5b75\u5316\u80da\u76e4\u80de\uff09\u3001\u5b50\u5bae\u5185\u819c\u306b\u7740\u5e8a\u3059\u308b\u3002\u305d\u306e\u5f8c\u3001\u80ce\u56a2\u3001\u5375\u9ec4\u56a2\u3001\u304a\u3088\u3073\u80ce\u5150\u3092\u5f62\u6210\u3059\u308b\u3002\uff08\u56f33\uff09<\/p>\n<h3><span id=\"i-5\">\u4f53\u5916\u53d7\u7cbe\u6642\u306b\u304a\u3051\u308b\u53d7\u7cbe\u5375\u306e\u767a\u80b2\uff0d\u521d\u671f\u80da\u306e\u8a55\u4fa1\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/span><\/h3>\n<p>\u4f53\u5185\u3067\u306e\u81ea\u7136\u306a\u53d7\u7cbe\u3068\u540c\u3058\u3088\u3046\u306b\u4f53\u5916\u53d7\u7cbe\u306e\u53d7\u7cbe\u5375\u306f\u767a\u80b2\u3059\u308b\u3002\u305d\u306e\u767a\u80b2\u904e\u7a0b\u306e\u4e2d\u306b\u3069\u306e\u6bb5\u968e\u3001\u3069\u306e\u5f62\u614b\u306e\u53d7\u7cbe\u5375\u3092\u9078\u629e\u3057\u3001\u5b50\u5bae\u5185\u8154\u306b\u79fb\u690d\u3059\u308c\u3070\u3001\u6700\u3082\u598a\u5a20\u7387\u304c\u9ad8\u304f\u826f\u3044\u7d50\u679c\u3092\u5f97\u3089\u308c\u308b\u306e\u304b\u3001\u3053\u308c\u3092\u8ffd\u6c42\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u306a\u8ab2\u984c\u3068\u306a\u308b\u3002\u80da\u306e\u8a55\u4fa1\u6642\u671f\u306f\u3001\u53d7\u7cbe\u5375\u304c\uff12\uff5e\uff13\u65e5\u76ee4\u7d30\u80de\u301c8\u7d30\u80de\u306e\u300c\u521d\u671f\u80da\u300d\u306e\u6642\u671f\u3001\u3082\u3057\u304f\u306f\u3001\uff15\uff5e\uff16\u65e5\u76ee\u306e\u304a\u3088\u305d100\uff5e200\u500b\u306e\u7d30\u80de\u3088\u308a\u306a\u308b\u300c\u80da\u76e4\u80de\u300d\u306e\u6642\u671f\u3067\u3042\u308b\u3002<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"1024\" src=\"\/takasago\/images\/2020\/06\/\u56f34\u3000Veeck-\u5206\u985e-3-768x1024.jpg\" alt=\"\" class=\"wp-image-1082\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f34\u3000Veeck-\u5206\u985e-3-768x1024.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f34\u3000Veeck-\u5206\u985e-3-225x300.jpg 225w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f34\u3000Veeck-\u5206\u985e-3.jpg 982w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><figcaption> <strong>\u56f3\uff14<\/strong> \u521d\u671f\u5206\u5272\u80da\uff08\u63a1\u5375\u5f8c\uff12\u65e5\u76ee\u306e\uff14\u7d30\u80de\u671f\u80da\u3068\uff14\u65e5\u76ee\u306e\uff18\u7d30\u80de\u671f\u80da\uff09\u306e\u8a55\u4fa1\u3068Veeck \u5206\u985e\uff082008\u5e7412\u6708 \u65e5\u7523\u5a66\u8a8c\uff09<strong>5\uff09<\/strong><br> Day2 \u7406\u60f3\u7684\u7d30\u80de\u6570\u306f\uff14\u7d30\u80de\u3001Day3 \u7406\u60f3\u7684\u7d30\u80de\u6570\u306f\uff18\u7d30\u80de\u3067\u3042\u308b\u3002<br> Veeck\u5206\u985e\u306f\u7d30\u80de\u306e\u6570\u3001\u7d30\u80de\u5206\u88c2\u306b\u3088\u308a\u751f\u3058\u305f\u7c92\u3005(fragmentation)\u306e\u5272\u5408\u3001\u7d30\u80de\u306e\u5927\u304d\u3055\u306e\u5747\u7b49\u6027\u3092\u8a55\u4fa1\u3059\u308b\u5206\u985e\u6cd5\u3067\u3042\u308b\u3002<br> \u25a0Grade1\u30fb\u7d30\u80de\u306e\u5927\u304d\u3055\u304c\u5747\u7b49\u3067\u3001fragmentation\u306f0\uff05<a>\u306e<\/a>\u80da<br> \u25a0Grade2\u30fb\u7d30\u80de\u306e\u5927\u304d\u3055\u304c\u5747\u7b49\u3067\u3001fragmentation\u306f15\uff05\u4ee5\u4e0b\u306e\u80da<br> \u25a0Grade3\u30fb\u7d30\u80de\u306e\u5927\u304d\u3055\u304c\u4e0d\u5747\u7b49\u3067\u3001fragmentation\u306f15\uff05\u4ee5\u4e0b\u306e\u80da<br> \u25a0Grade4\u30fb\u7d30\u80de\u306e\u5927\u304d\u3055\u304c\u5747\u7b49or\u4e0d\u5747\u7b49\u3067\u3001fragmentation\u306f20\uff5e50\uff05\u306e\u80da<br> \u25a0Grade5\u30fb\u7d30\u80de\u3092\u307b\u3068\u3093\u3069\u8a8d\u3081\u305a\u3001 fragmentation\u306f50\uff05\u4ee5\u4e0a\u306e\u80da <\/figcaption><\/figure>\n\n\n<p>Grade 1\u306e\u80da\u306f\u7d30\u80de\u306e\u5927\u304d\u3055\u304c\u5747\u7b49\u3067\u3001fragmentation\u306f0\uff05\u306e\u80da\u3067\u4e00\u756a\u8cea\u304c\u3088\u3044\u80da\u3067\u3042\u308b\u3002\u67d3\u8272\u4f53\u306e\u7570\u5e38\u3082\u6bd4\u8f03\u7684\u306b\u5c11\u306a\u304f\u79fb\u690d\u3059\u308c\u3070\u598a\u5a20\u3057\u3084\u3059\u3044\u3002\u9006\u306bGrade 5\u306e\u80da\u306f\u7d30\u80de\u3092\u307b\u3068\u3093\u3069\u8a8d\u3081\u305a\u3001 fragmentation\u3082\u304b\u306a\u308a\u8457\u3057\u3044\u80da\u3067\u3042\u308b\u3002\u67d3\u8272\u4f53\u306e\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u79fb\u690d\u80da\u306b\u306f\u9069\u3055\u306a\u3044\u3002<\/p>\n\n\n<h3><span id=\"ART5\"><a id=\"d3pregrate\"><\/a>\u53d7\u7cbe\uff13\u65e5\u76ee\u5206\u5272\u80da\u306e\u7d30\u80de\u6570\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f3\uff15\uff09<\/span><\/h3>\n\n\n<p>Veeck\u5206\u985e\u306eGrade \u3068\u5171\u306b\u9069\u5207\u306a\u7d30\u80de\u6570\u3082\u598a\u5a20\u7387\u3092\u5927\u304d\u304f\u5de6\u53f3\u3059\u308b\u3002\u53d7\u7cbe\u3057\u3066\uff13\u65e5\u76ee\u306e\u53d7\u7cbe\u5375\u306f\uff13\u56de\u306e\u7d30\u80de\uff12\u7b49\u5206\u5206\u88c2\u3092\u5b8c\u6210\u3057\uff18\u7d30\u80de\u3068\u306a\u308b\u3002\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802 \u306e2014\u5e74\uff5e2018\u5e74\u306b\u884c\u3063\u305f\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u5206\u5272\u80da\uff08Day\uff13\uff09\u79fb\u690d428\u5468\u671f\uff087cell\uff5e\u3001G1\uff5e3\u3001\u51cd\u7d50\uff11\u56de\u3092\u5bfe\u8c61\u80da\uff09\u306e\u7d30\u80de\u6570\u5225\u81e8\u5e8a\u598a\u5a20\u7387\u3092\u691c\u8a0e\u3057\u3001\u56f3\uff15\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"668\" class=\"wp-image-1083\" alt=\"\" src=\"\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph-1024x668.jpg\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph-1024x668.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph-300x196.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph-768x501.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph-1536x1002.jpg 1536w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f35\u3000Day3\u598a\u5a20\u7387BarGraph.jpg 1661w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\n<figcaption><strong>\u56f3\uff15<\/strong>\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u5206\u5272\u80da\uff08DAY\uff13\uff09\u79fb\u690d\u306e\u7d30\u80de\u6570\u5225\u81e8\u5e8a\u598a\u5a20\u7387<br>\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802 2014\u5e74\uff5e2018\u5e74\u306e\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d428\u5468\u671f\u306e\u6210\u7e3e\uff087cell\uff5e\u3001G1\uff5e3\u3001\u51cd\u7d50\uff11\u56de\u3092\u5bfe\u8c61\u80da\u3068\u3059\u308b\uff09<\/figcaption>\n<\/figure>\n\n\n<p>\u5168\u4f53\u306e\u7d0462\uff05\u306e267\u5468\u671f\u3067\u3001\uff18\u7d30\u80de\u5206\u5272\u80da\u306e\u79fb\u690d\u3092\u884c\u3044\u3001\u6700\u3082\u9ad8\u3044\u598a\u5a20\u738731.8\uff05\u3068\u306a\u3063\u305f\u3002\uff17\u7d30\u80de\u80da\u306e\u79fb\u690d\u306f\u3001\u7d0410\uff05\u306e42\u4f8b\u3067\u3001\u598a\u5a20\u7387\u306f16.7\uff05\u3068\u6700\u3082\u4f4e\u304b\u3063\u305f\u3002\uff19\u7d30\u80de\u80da\u306e\u79fb\u690d\u306f\u7d0411\uff05\u306e48\u4f8b\u3067\u3001\u598a\u5a20\u738722.9\uff05\u3067\u3042\u3063\u305f\u300210\u7d30\u80de\u4ee5\u4e0a\u306e\u80da\u306f\u7d0417\uff05\u306e71\u4f8b\u3067\u3001\u598a\u5a20\u7387\u306f22.5\uff05\u3068\u3001\uff19\u7d30\u80de\u80da\u3068\u540c\u7b49\u3067\u3042\u3063\u305f\u3002<\/p>\n<h2><span id=\"i-6\"><a id=\"embryoblast\"><\/a>\u80da\u76e4\u80de\u306e\u8a55\u4fa1\u6cd5\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/span><\/h2>\n\n\n<h3><span id=\"ICMTEES\">\u80da\u76e4\u80de\u306eICM\u3068TE\u7d30\u80de\u306e\u5206\u5316\u3068ES\u7d30\u80de<\/span><\/h3>\n\n\n\n<p>\u53d7\u7cbe\uff14\u65e5\u76ee\u6851\u5b9f\u80da\u306e\u6642\u671f\u306b\u304a\u3044\u3066\u3001\u5916\u5074\u306e\u7d30\u80de\u306e\u307f\u306bCdx2\u304c\u9ad8\u983b\u5ea6\u306b\u307f\u3089\u308c\u308b\u3002Cdx2\u306f\u80da\u306e\u7d30\u80de\u3092\u6804\u990a\u82bd\u5c64\u3078\u306e\u5206\u5316\u8a98\u5c0e\u56e0\u5b50\u3067\u3042\u308b\u3002\u5c06\u6765\u80ce\u76e4\u3092\u5f62\u6210\u3059\u308b\u7d30\u80de\u3067\u3042\u308b\u6804\u990a\u5916\u80da\u8449(TE, Trophectoderm)\u3092\u5916\u5074\u306b\u3001\u5c06\u6765\u3001\u80da\u4f53\u3092\u5f62\u6210\u3059\u308b\u591a\u80fd\u6027\u7d30\u80de\u96c6\u56e3\u3067\u3042\u308b\u5185\u90e8\u7d30\u80de\u584a\uff08ICM, Inner Cell Mass)\u3092\u5185\u5074\u306b\u6301\u3064\u3001\u80da\u76e4\u80de\u3068\u547c\u3070\u308c\u308b\u5f62\u614b\u3092\u5f62\u6210\u3059\u308b\u3002\u53c8\u3001\u7740\u5e8a\u76f4\u524d\u306e\u767a\u751f\u6bb5\u968e\u306b\u5916\u5074\u304b\u3089\u5185\u5074\u3078\u3068\u79fb\u52d5\u3057\u305f\u7d30\u80de\u3067\u306fCdx2\u306e\u767a\u73fe\u306f\u5f90\u3005\u306b\u6291\u5236\u3055\u308c\u3001\u6700\u7d42\u7684\u306b\u306f\u5143\u3005\u5185\u5074\u306b\u3044\u305f\u7d30\u80de\u3068\u5354\u8abf\u3057\u3066\u5185\u90e8\u7d30\u80de\u584a\u3092\u5f62\u6210\u3057\u3001\u591a\u80fd\u6027\u306e\u7d30\u80de\u96c6\u56e3\u306b\u767a\u80b2\u3059\u308b\u3002\uff08\u56f36\uff09\uff08\u56f3\uff17\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"715\" height=\"414\" src=\"\/takasago\/images\/2020\/06\/\u56f36\u3000\u4e00\u5ea6Cdx2\u3092\u9ad8\u767a\u73fe\u3057\u305f\u5f8c\u306b\u5916\u5074\u304b\u3089\u5185\u5074\u306b\u79fb\u52d5\u3057\u305f\u7d30\u80de-4.jpg\" alt=\"\" class=\"wp-image-1084\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f36\u3000\u4e00\u5ea6Cdx2\u3092\u9ad8\u767a\u73fe\u3057\u305f\u5f8c\u306b\u5916\u5074\u304b\u3089\u5185\u5074\u306b\u79fb\u52d5\u3057\u305f\u7d30\u80de-4.jpg 715w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f36\u3000\u4e00\u5ea6Cdx2\u3092\u9ad8\u767a\u73fe\u3057\u305f\u5f8c\u306b\u5916\u5074\u304b\u3089\u5185\u5074\u306b\u79fb\u52d5\u3057\u305f\u7d30\u80de-4-300x174.jpg 300w\" sizes=\"auto, (max-width: 715px) 100vw, 715px\" \/><figcaption> <a><strong>\u56f3\uff16<\/strong><\/a>\u3000\u6851\u5b9f\u80da\u304b\u3089\u80da\u76e4\u80de\u3078\u3001\u6804\u990a\u5916\u80da\u8449(TE, Trophectoderm)\u3068\u5185\u90e8\u7d30\u80de\u584a\uff08ICM, Inner Cell Mass)\u306e\u5206\u5316\u3092\u793a\u3057\u305f\u56f3\u3002<br> \uff08\u8c4a\u5ca1\u3084\u3088\u3044\u3001\u85e4\u68ee\u4fca\u5f66\u3001\u57fa\u790e\u751f\u7269\u5b66\u7814\u7a76\u6240\u30012016.02.16\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1bYayoi Toyooka, Sanae Oka, Toshihiko Fujimori\u3001Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes\u3001Developmental Biology\u3001Volume 411, Issue 1, 1 March 2016, Pages 50-60 \u4e00\u90e8\u6539\u7de8\uff09<strong>6) 7)<\/strong> <\/figcaption><\/figure>\n\n\n\n<h3><span id=\"_ES_cells_Embryonic_stem_cells\">\u80da\u6027\u5e79\u7d30\u80de ES cells (Embryonic stem cells)<\/span><\/h3>\n\n\n\n<p>\u53d7\u7cbe\u5375\u3068\u5206\u5272\u80da\u306f\u500b\u4f53\u3092\u4f5c\u308a\u3060\u305b\u308b\u3059\u3079\u3066\u306e\u7d30\u80de\u3078\u306e\u5206\u5316\u80fd\u529b\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u5168\u80fd\u6027(totipotency)\u3068\u547c\u3070\u308c\u308b\u3002\u80da\u76e4\u80de\u306b\u306f\u3001\u4f53\u3092\u69cb\u6210\u3059\u308b\u5168\u3066\u306e\u7d44\u7e54\u7d30\u80de\u3084\u751f\u6b96\u7d30\u80de\u306b\u5206\u5316\u3067\u304d\u308b\u672a\u5206\u5316\u306a\u5e79\u7d30\u80de\u304c\u3042\u308a\u3001\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08pluripotent stem cells\uff09\u3068\u547c\u3076\u3002\u4e00\u65b9\u3001\u539f\u8178\u80da\u306e\u3001\u4f53\u6027\u5e79\u7d30\u80de\u306e\u591a\u304f\u306f\u751f\u6b96\u7d30\u80de\u4ee5\u5916\u306e\u7d44\u7e54\u7d30\u80de\u306b\u5206\u5316\u3067\u304d\u308b\u9650\u5b9a\u7684\u306a\u591a\u80fd\u6027\u3092\u3082\u3061\uff0cmultipotent stem cells\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u308b\u3002\u80da\u76e4\u80de\u306e\u5185\u90e8\u7d30\u80de\u584aICM\u3092\u53d6\u308a\u51fa\u3057\u57f9\u990a\u3057\u305f\u3082\u306e\u304c\u3001\u8eab\u4f53\u306e\u3042\u3089\u3086\u308b\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u3067\u518d\u751f\u533b\u7642\u306e\u5206\u91ce\u3067\u6ce8\u76ee\u3092\u6d74\u3073\u305f\u3002\u3044\u308f\u3086\u308bES\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001\u6804\u990a\u5916\u80da\u8449\u306f\u80ce\u76e4\u3084\u7f8a\u819c\u306a\u3069\u306e\u80da\u5916\u7d44\u7e54\u306b\u5206\u5316\u3057\u3066\u3044\u304f\u3002\u56f3\uff16\u3001\u56f3\uff17\u30018)<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"672\" src=\"\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3-1024x672.jpg\" alt=\"\" class=\"wp-image-1085\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3-1024x672.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3-300x197.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3-768x504.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3-1536x1008.jpg 1536w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f37\u3000ES-cell-\u7cfb\u5217\u56f3.jpg 1567w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <a><strong>\u56f3\uff17<\/strong><\/a><strong> <\/strong>\u80da\u76e4\u80de\u306e\u69cb\u9020\u3068ES\u7d30\u80de\u3000<br> \u80da\u76e4\u80de\u306e\u5185\u90e8\u7d30\u80de\u584a\u7d30\u80de\uff08ICM\uff09\u3092\u53d6\u308a\u51fa\u3057\u3066\u57f9\u990a\u76bf\u3067\u57f9\u990a\u3059\u308b\u3068\u3001\u9577\u671f\u9593\u5897\u6b96\u3057\u3066\u3082\u591a\u5206\u5316\u80fd\u3092\u7dad\u6301\u3057\u7d9a\u3051\u3089\u308c\u308b\u5e79\u7d30\u80de\u304c\u73fe\u308c\u308b\u3002\u3053\u308c\u304c\u80da\uff08Embryo\uff09\u7531\u6765\u306e\u5e79\u7d30\u80de\u3067ES\u7d30\u80de(embryonic stem cells)\u3067\u3042\u308b\u3002\uff08Ismael Galve-Roperh\u3089\u306e Cannabinoid receptor signaling in progenitor\/stem cell proliferation and differentiation <strong>8)<\/strong>\u3088\u308a\u6539\u7de8 ) <\/figcaption><\/figure>\n\n\n<h3><span id=\"Gardner\">\u80da\u76e4\u80de\u306e\u8a55\u4fa1\u6cd5\u30fbGardner \u5206\u985e<\/span><\/h3>\n<p>\u53d7\u7cbe\uff14\u65e5\u76ee32\u7d30\u80de\u306e\u6851\u5b9f\u80da\uff08Morula\uff09\u304b\u3089\u66f4\u306b\u7d30\u80de\u306f\u5206\u88c2\u3057\u3001\u6c34\u3092\u4e2d\u306b\u53d6\u308a\u8fbc\u3093\u3067\u80de\u80da\u8154\u3092\u5f62\u6210\u3057\u3001\uff15\uff5e\uff16\u65e5\u76ee\u306b\u304a\u3088\u305d100\uff5e200\u500b\u306e\u7d30\u80de\u306e\u80da\u76e4\u80de\u3068\u306a\u308b\u3002\u80de\u80da\u8154\u306f\u62e1\u5927\u3057\u3064\u3064\u3001\u5185\u7d30\u80de\u584a\u3068\u6804\u990a\u5916\u80da\u8449\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u6570\u3082\u5897\u6b96\u3057\u3066\u3044\u304f\u7a0b\u598a\u5a20\u7387\u304c\u9ad8\u304f\u306a\u308b\u3002\u5f93\u3063\u3066\u80da\u76e4\u80de\u306e\u5f62\u614b\u7684\u8a55\u4fa1\u306f\u79fb\u690d\u7740\u5e8a\u306e\u6210\u5426\u306b\u306f\u5927\u4e8b\u306a\u8ab2\u984c\u306b\u306a\u308b\u3002 Gardner\u306e\u5206\u985e\uff081999\u5e74\uff09\u306f\uff0c\u80da\u76e4\u80de\u306e\u30b9\u30c6\u30fc\u30b8\u30926\u6bb5\u968e\u306b\uff0c\u3055\u3089\u306bICM\u304a\u3088\u3073 Trophectoderm\u306e\u5f62\u614b\u30923\u6bb5\u968e\u306b\u5206\u985e\u3059\u308b\uff0e\u79fb\u690d\u80da\u304c3AA\u4ee5\u4e0a\uff0c\u3059\u306a\u308f\u3061\u80de\u80da\u8154\u304c\u80da\u5168\u4f53\u306b\u53ca\u3073\uff0cICM\u304c\u591a\u6570\u306e\u7d30\u80de\u3088\u308a\u5f62\u6210\u3055\u308c\u5bc6\u96c6\u3057\uff0c\u6804\u990a\u5916\u80da\u8449\u3082\u591a\u6570\u306e\u7d30\u80de\u304b\u3089\u306a\u308a\u3001\u305d\u306e\u7d50\u5408\u304c\u5bc6\u3067\u3042\u308b\u80da\u76e4\u80de\u3092\u79fb\u690d\u3059\u308b\u3068\uff0c\u305d\u306e\u598a\u5a20\u7387\u304c\u9ad8\u7387\u3068\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\uff08\u56f3\uff18\uff09<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"885\" height=\"1024\" src=\"\/takasago\/images\/2020\/06\/\u56f38\u3000\u80da\u76e4\u80de-\u5206\u985e-2-885x1024.jpg\" alt=\"\" class=\"wp-image-1088\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f38\u3000\u80da\u76e4\u80de-\u5206\u985e-2-885x1024.jpg 885w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f38\u3000\u80da\u76e4\u80de-\u5206\u985e-2-259x300.jpg 259w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f38\u3000\u80da\u76e4\u80de-\u5206\u985e-2-768x889.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f38\u3000\u80da\u76e4\u80de-\u5206\u985e-2.jpg 1173w\" sizes=\"auto, (max-width: 885px) 100vw, 885px\" \/><figcaption> <strong>\u56f3\uff18\u3000<\/strong>\u80da\u76e4\u80de\u306e\u8a55\u4fa1\u6cd5\u30fbGardner \u5206\u985e\uff082008\u5e7412\u6708 \u65e5\u7523\u5a66\u8a8c\uff09<a><strong>4<\/strong><\/a><strong>\uff09<\/strong> <\/figcaption><\/figure>\n\n\n<h2><span id=\"Day56\">\u80da\u76e4\u80de(Day5,6)\u5f62\u614b\u7684\u8a55\u4fa1\u3068\u598a\u5a20\u7387\u306e\u95a2\u4fc2<\/span><\/h2>\n<p>\u80da\u76e4\u80de\u306f\u767a\u80b2\u3059\u308b\u306b\u3057\u305f\u304c\u3044\u80de\u80da\u8154\u304c\u5927\u304d\u304f\u306a\u308a\u3001\u5b75\u5316\u3059\u308b\u3002Gardner \u5206\u985e\u3067\u306f\u3001\u305d\u306e\u767a\u80b2\u6bb5\u968e\u3092Stage 1\uff5e6\u306b\u5206\u985e\u3059\u308b\u3002\u305d\u306e\u3046\u3061\u3001Stage 3\u4ee5\u4e0a\u306e\u80da\u76e4\u80de\u306f\u3001\u3055\u3089\u306bGrade\u3068\u3057\u3066\u3001\u5185\u7d30\u80de\u584a\u3068\u6804\u990a\u5916\u80da\u8449\u306e\u7d30\u80de\u6570\u306b\u3088\u3063\u3066A\u301cC\u306b\u7d30\u5206\u985e\u3059\u308b\u3002\u5185\u7d30\u80de\u584aICM\u306f\u5c06\u6765\u80ce\u5150\u306b\u306a\u308b\u90e8\u5206\u3067\u3001\u7d30\u80de\u6570\u304c\u591a\u304f\u5bc6\u3067\u3042\u308b\u307b\u3069\u826f\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u6804\u990a\u5916\u80da\u8449TE\u3068\u306f\u5c06\u6765\u80ce\u76e4\u306b\u306a\u308b\u90e8\u5206\u3067\u3001\u7d30\u80de\u6570\u304c\u591a\u304f\u5bc6\u3067\u3042\u308b\u307b\u3069\u826f\u3044\u3068\u3055\u308c\u308b\u3002Gardner \u5206\u985e\u3067\u306f\u3001\u767a\u80b2\u6bb5\u968e\uff08\u80de\u80da\u8154\u306e\u5927\u304d\u3055\u3001Stage1\uff5e6 \uff09\u3068\u5185\u7d30\u80de\u584a\u3001\u6804\u990a\u5916\u80da\u8449\u306e\u7d30\u80de\u6570\uff08Grade A.B,C\uff09\u306b\u3088\u308a\u5206\u985e\u3059\u308b\uff08\u56f3\uff18\uff09\u3002Stage \u306e\u6570\u5024\u304c\u9ad8\u304f\u3001AA\u306b\u8fd1\u3044\u3082\u306e\u304c\u8cea\u306e\u9ad8\u3044\u80da\u76e4\u80de\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u67d3\u8272\u4f53\u7570\u5e38\u306e\u983b\u5ea6\u4f4e\u304f\u3001\u7740\u5e8a\u7387\u304c\u9ad8\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002\u57fa\u672c\u7684\u306bStage 3\u4ee5\u4e0a\u30013BB\u4ee5\u4e0a\u3092\u826f\u597d\u80da\u3068\u5224\u65ad\u3057\u79fb\u690d\u306e\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>\u4eca\u56de\u3001\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802 2014\u5e74\uff5e2018\u5e74\u306e\u8a08\uff15\u5e74\u9593\u3067\u57f9\u990a\uff15\uff5e\uff16\u65e5\u76ee\u306e\u80da\u76e4\u80de\u3092\u51cd\u7d50\u3057\u3001\u5225\u306e\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u5468\u671f\u306b\u5358\u4e00\u878d\u89e3\u80da\u79fb\u690d\u3057\u305f\u3001654\u5468\u671f\u306e\u81e8\u5e8a\u598a\u5a20\u7387\u3092\u89e3\u6790\u3057\u305f\u3002\u79fb\u690d\u80da\u306f\u3001Gardner\u5206\u985eStage 3\u4ee5\u4e0a\u3001\u51cd\u7d50\uff11\u56de\u3001Grade C\u3082\u5bfe\u8c61\u80da\u3068\u3057\u305f\u3002<br>\u80de\u80da\u8154\u62e1\u5f35Stage\u5225\uff08\u56f3\uff19\uff09\u81e8\u5e8a\u598a\u5a20\u7387\u53ca\u3073ICM\/TE Grade\u5225\uff08\u56f310\uff09\u81e8\u5e8a\u598a\u5a20\u7387\u3092\u691c\u8a0e\u3057\u3001\u4ee5\u4e0b\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002<\/p>\n<h3><span id=\"StageART5\"><a id=\"d5pregrate\"><\/a>\u80de\u80da\u8154\u62e1\u5f35Stage\u5225\u81e8\u5e8a\u598a\u5a20\u7387\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f3\uff19\uff09<\/span><\/h3>\n<p>Stage 3\u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d0417\uff05\u3001110\u5468\u671f\u3001\u598a\u5a20\u7387\u306f35.5\uff05\u3067\u3042\u3063\u305f\u3002Stage 4 \u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d0480\uff05\u3001520\u5468\u671f\u3068\u9ad8\u3044\u30a6\u30a7\u30a4\u30c8\u3092\u793a\u3057\u3001\u598a\u5a20\u7387\u306f47.1\uff05\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u6210\u7e3e\u306fStage 3 \u306e\u598a\u5a20\u7387 \u3088\u308a\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08Chi-square test\u3001p &lt; 0.05) \u3002 Stage 5 \u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d044\uff05\u300124\u5468\u671f\u3067\u3001\u598a\u5a20\u7387\u306f58.3\uff05\u3068\u6700\u3082\u826f\u3044\u7d50\u679c\u306b\u306a\u3063\u305f\u3002\u3053\u306e\u6210\u7e3e\u306fStage 3 \u306e\u598a\u5a20\u7387 \u3088\u308a\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08Chi-square test\u3001p &lt; 0.05) \u3002Stage 6 \u306b\u8a72\u5f53\u3059\u308b\u5468\u671f\u306f\u306a\u304b\u3063\u305f\u3002\u5168654\u5468\u671f\u306e\u598a\u5a20\u7387\u306f45.6\uff05\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"882\" src=\"\/takasago\/images\/2020\/06\/\u56f39\u3000\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80deStage\u5225\u598a\u5a20\u7387-1024x882.jpg\" alt=\"\" class=\"wp-image-1089\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f39\u3000\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80deStage\u5225\u598a\u5a20\u7387-1024x882.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f39\u3000\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80deStage\u5225\u598a\u5a20\u7387-300x258.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f39\u3000\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80deStage\u5225\u598a\u5a20\u7387-768x661.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f39\u3000\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80deStage\u5225\u598a\u5a20\u7387.jpg 1497w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> \u56f3\uff19\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802 2014\uff5e2018\u5e74\u306e5\u5e74\u9593\u306b\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80de 654 \u56de\u79fb\u690d\u5468\u671f\uff08Stage 3\uff5e\u3001\u51cd\u7d50\uff11\u56de\u3001Grade C\u3082\u5bfe\u8c61\u80da\uff09\u306e\u80de\u80da\u8154\u62e1\u5f35Stage\u5225\u81e8\u5e8a\u598a\u5a20\u7387<br> &nbsp; <\/figcaption><\/figure>\n\n\n<h3><span id=\"ICMTE_GradeART5-10\"><a id=\"ICMTEpregrate\"><\/a>\u5185\u7d30\u80de\u584aICM\/\u6804\u990a\u5916\u80da\u8449TE Grade\u5225\u81e8\u5e8a\u598a\u5a20\u7387\uff08\u5927\u5dddART5\u5e74\u6210\u7e3e-\u56f310\uff09<\/span><\/h3>\n<p>Grade AA \u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d0444\uff05\u3001287\u5468\u671f\u3068\u6700\u3082\u591a\u304f\u3001\u598a\u5a20\u7387\u306f55.7\uff05\u3068\u6700\u3082\u9ad8\u3044\u6210\u7e3e\u3067\u3042\u308b\u3002Grade AB,BA \u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d0438\uff05\u3001247\u5468\u671f\u3067\u3001\u598a\u5a20\u7387\u306f38.9\uff05\u3067\u3042\u308b\u3002Grade BB \u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d0417\uff05\u3001114\u5468\u671f\u3067\u3001\u598a\u5a20\u7387\u306f36.0\uff05\u3067\u3042\u308b\u3002Grade &lt;BB\u306e\u5468\u671f\u306f\u7dcf\u6570\u306e\u7d041\uff05 6\u5468\u671f\u3068\u3054\u304f\u5c11\u6570\u3067\u3001\u598a\u5a20\u7387\u306f16.7\uff05\u3067\u3042\u3063\u305f\u3002 Grade AA \u306e\u598a\u5a20\u738755.7\uff05\u306fGrade AB,BA \u306e\u598a\u5a20\u738738.9\uff05\u3088\u308a\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u305f (Chi-square test: \u03c72=15.16 , p &lt; 0.001 ) \u3002\u53c8\u3001 Grade AA \u306e\u598a\u5a20\u738755.7\uff05\u306fGrade BB \u306e\u598a\u5a20\u738736.0\uff05 \u3088\u308a\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u305f(Chi-square test: \u03c72=12.77 , p &lt; 0.001) \u3002<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"782\" src=\"\/takasago\/images\/2020\/06\/\u56f310\u65b0\u3000\u80da\u76e4\u80deGrade\u5225\u598a\u5a20\u7387-1024x782.jpg\" alt=\"\" class=\"wp-image-1090\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f310\u65b0\u3000\u80da\u76e4\u80deGrade\u5225\u598a\u5a20\u7387-1024x782.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f310\u65b0\u3000\u80da\u76e4\u80deGrade\u5225\u598a\u5a20\u7387-300x229.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f310\u65b0\u3000\u80da\u76e4\u80deGrade\u5225\u598a\u5a20\u7387-768x587.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f310\u65b0\u3000\u80da\u76e4\u80deGrade\u5225\u598a\u5a20\u7387.jpg 1505w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <strong>\u56f310 <\/strong>\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802 2014\uff5e2018\u5e74\u306e5\u5e74\u9593\u306b\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u76e4\u80de 65<strong>4<\/strong> \u4ef6\u79fb\u690d\u5468\u671f\uff08Stage 3\uff5e\u3001\u51cd\u7d50\uff11\u56de\u3001Grade C<strong>\u3082<\/strong>\u5bfe\u8c61\u80da\uff09\u306e\u5185\u7d30\u80de\u584aICM\/\u6804\u990a\u5916\u80da\u8449TE&nbsp; Grade\u5225\u81e8\u5e8a\u598a\u5a20\u7387\u3000 <\/figcaption><\/figure>\n\n\n<h2><span id=\"i-7\">\u8003 \u5bdf<\/span><\/h2>\n<p>\u4eca\u56de\u306e\u5358\u4e00\u51cd\u7d50\u878d\u89e3\u80da\u79fb\u690d\u306b\u304a\u3044\u3066\u3001Day3\u5206\u5272\u80da\u79fb\u690d\u3067\u306f\u3001Veeck\u5206\u985e\u3000Grade3\u4ee5\u4e0a\u306e\uff18\u7d30\u80de\u80da\u306e\u79fb\u690d\u306f\u6700\u3082\u9ad8\u3044\u598a\u5a20\u738731.8\uff05\u304c\u5f97\u3089\u308c\u305f\u3002\u4e00\u65b9\u3001Day5,6\u306e\u80da\u76e4\u80de\u79fb\u690d\u3067\u306f\u3001Gardner\u5206\u985e\u3067\u3001\u80de\u80da\u8154\u62e1\u5f35\u304c\u5927\u304d\u3051\u308c\u3070\u79fb\u690d\u306e\u598a\u5a20\u7387\u3082\u9ad8\u304f\u306a\u308a\u3001\uff08Stage 3,4,5 : 36.1%,46.7%,53.8%)\u3000\u5185\u7d30\u80de\u584aICM\/\u6804\u990a\u5916\u80da\u8449TE\u306e Grade\u9078\u5225\u304b\u3089ICM\u7d30\u80de\u3001TE\u7d30\u80de\u304c\u591a\u304f\u3067\u5bc6\u3067\u3042\u308c\u3070\u79fb\u690d\u306e\u598a\u5a20\u7387\u306f\u9ad8\u304f\u306a\u308b\u50be\u5411\u306b\u3042\u3063\u305f\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001\u79fb\u690d\u80da\u306e\u9078\u5225\u65b9\u3068\u3057\u3066\u3001\u5206\u5272\u80da\u79fb\u690d\u3067\u306fVeeck\u5206\u985e\u6cd5\u3001\u80da\u76e4\u80de\u79fb\u690d\u3067\u306fGardner\u5206\u985e\u6cd5\u304c\u3001\u7c21\u4fbf\u3067\u6709\u7528\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u518d\u8a8d\u8b58\u3067\u304d\u305f\u3002<\/p>\n<h3><span id=\"i-8\">\u5973\u6027\u306e\u5e74\u9f62\u3068\u80da\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027<\/span><\/h3>\n<p>\u305f\u3060\u3057\u3001Gardner\u5206\u985e5AA\u306e\u80da\u3067\u3042\u3063\u3066\u3082\u598a\u5a20\u7387\u306f100\uff05\u3067\u306f\u306a\u304f\u3001\u672c\u7814\u7a76\u3067\u306f\u598a\u5a20\u738759\uff05\u306b\u3068\u3069\u307e\u3063\u3066\u304a\u308a\u3001\u7d04\uff14\u5272\u306e\u80da\u306f\u598a\u5a20\u306b\u81f3\u3089\u306a\u304b\u3063\u305f\u3002\u305d\u306e\u4e3b\u306a\u8981\u56e0\u306f\u80da\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u5b58\u5728\u304c\u8003\u3048\u3089\u308c\u305f\u3002\u5973\u6027\u306e\u5e74\u9f62\u304c\u4e0a\u6607\u3059\u308b\u3068\u80da\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027aneuploidy \u306e\u767a\u751f\u7387\u306f\u4e0a\u6607\u3057\u3001\u7740\u5e8a\u7387\u306f\u4e0b\u964d\u3057\u3001\u6d41\u7523\u7387\u3001\u5150\u306e\u67d3\u8272\u4f53\u7570\u5e38\u306e\u30ea\u30b9\u30af\u3082\u5897\u52a0\u3059\u308b\u30022014\u5e74Jason M.\u3089\u306f15,169\u500b\u80da\u76e4\u80de\u306e\u6804\u990a\u5916\u80da\u8449 (Trophectoderm)\u7d30\u80de\u751f\u691c\u3088\u308a\u5973\u6027\u5e74\u9f62\u3068\u80da\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u95a2\u9023\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u80da\u67d3\u8272\u4f53\u7570\u6570\u6027\u306f30\u6b73\u306e20\uff05\u53f0\u304b\u3089\u6025\u6fc0\u306b\u4e0a\u6607\u3057\u300144\u6b73\u306b\u306f\u7d0490\uff05\u306b\u9054\u3057\u3066\u3044\u308b\u3002\u56f311\u30019)<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"679\" src=\"\/takasago\/images\/2020\/06\/\u56f311\u3000A-The-prevalence-of-aneuploidy-relative-to-the-age-1024x679.jpg\" alt=\"\" class=\"wp-image-1091\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f311\u3000A-The-prevalence-of-aneuploidy-relative-to-the-age-1024x679.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f311\u3000A-The-prevalence-of-aneuploidy-relative-to-the-age-300x199.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f311\u3000A-The-prevalence-of-aneuploidy-relative-to-the-age-768x509.jpg 768w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f311\u3000A-The-prevalence-of-aneuploidy-relative-to-the-age.jpg 1362w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <strong>\u56f311<\/strong> \u5973\u6027\u5e74\u9f62\u3068\u80da\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u95a2\u9023\uff0815<strong>,<\/strong>169\u500b\u80da\u76e4\u80de\u306e\u6804\u990a\u5916\u80da\u8449 (Trophectoderm)\u7d30\u80de\u751f\u691c\u306e\u7d50\u679c\uff09 <strong>9)<\/strong><br> \u7279\u306b\u82e5\u3044\u5973\u6027\u306e\u80da\u67d3\u8272\u4f53\u7570\u6570\u6027\u306f40\uff05\u53f0\u3068\u9ad8\u3044\u304c\u300126\uff5e30\u6b73\u306f\u6700\u3082\u4f4e\u304f20\uff05\u53f0\u3067\u3042\u308b\u300230\u6b73\u4ee5\u5f8c\u306f\u307b\u307c\u76f4\u7dda\u7684\u95a2\u4fc2\u4e0a\u6607\u3057\u300144\u6b73\u306b\u306f90\uff05\u306b\u9054\u3057\u3066\u884c\u304f\u3002 <\/figcaption><\/figure>\n\n\n<h3><span id=\"i-9\">\u80da\u76e4\u80de\u306e\u80de\u80da\u8154\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u7570\u6570\u6027<\/span><\/h3>\n<p>2011\u5e74Samer\u308910) \u306f\u5168Grade\u306e\u80da\u76e4\u80de\u306b\u304a\u3044\u3066\u3001\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u80da\u306f\u534a\u6570\u4ee5\u4e0a\u3092\u5360\u3081\u308b\u3053\u3068\u306b\u7740\u76ee\u3057\u305f\u3002\u80da\u306e\u6210\u9577\u304c\u9045\u304f\u3001Grade\u304c\u5c0f\u3055\u3044\u7a0b\u306b\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\u78ba\u7387\u3068\u91cd\u75c7\u5ea6\u304c\u8457\u660e\u306b\u306a\u308b\u3002\u56f312\u300110\uff09\u4e00\u3064\u8208\u5473\u3092\u611f\u3058\u308b\u306e\u306f\u3001\u6210\u9577\u306e\u65e9\u3044\u80da\uff08Grade 5,6\uff09\u306e\u7570\u6570\u6027\u80da\u306e\u3046\u3061\u3001Trisomy\/Monosomy(=1.7) \u306e\u6bd4\u7387\u306f\u4ed6\u7fa4\u3088\u308a\u9ad8\u304f\u3001Trisomy\uff08\uff13\u500d\u4f53\u306f\u4e00\u90e8\u751f\u5b58\u53ef\u80fd\uff09 \u306fMonosomy\uff08\u5358\u500d\u4f53\u306f\u81f4\u6b7b\u7684\uff09 \u3088\u308a\u4e88\u5f8c\u304c\u826f\u3044\u3053\u3068\u304b\u3089\u3001\u598a\u5a20\u7387\u306f\u66f4\u306b\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u9006\u306b\u3001\u767a\u80b2\u306e\u9045\u3044\u80da(grade \u22643)\u306e\u91cd\u75c7\u67d3\u8272\u4f53\u7570\u6570\u6027\uff082\u672c\u30683\u672c\u4ee5\u4e0a\u67d3\u8272\u4f53\u306b\u53ca\u3076\u7570\u6570\u6027\uff09\u306f\u767a\u80b2\u826f\u597d\u80da(grade 5\u30016)\u306e\u91cd\u75c7\u67d3\u8272\u4f53\u7570\u6570\u6027\u306e\uff12\u500d\u4ee5\u4e0a\u3068\u5206\u304b\u3063\u305f\u3002\u5f93\u3063\u3066\u80da\u76e4\u80de\u306e\u5f62\u614b\u7684\u8a55\u4fa1\u5206\u985e\u306f\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u3084\u5404\u7a2e\u7570\u6570\u6027\u306e\u51fa\u73fe\u983b\u5ea6\u3068\u5bc6\u5207\u306a\u95a2\u4fc2\u304c\u3042\u308b\u3068\u307f\u3089\u308c\u308b\u300210)\uff08\u56f312\uff09<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"782\" height=\"498\" src=\"\/takasago\/images\/2020\/06\/\u56f312\u3000\u80da\u76e4\u80de\u5f62\u614b\u7684\u8a55\u4fa1\u3088\u308a\u80de\u80da\u8154\u306e\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u306e\u95a2\u4fc2.jpg\" alt=\"\" class=\"wp-image-1092\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f312\u3000\u80da\u76e4\u80de\u5f62\u614b\u7684\u8a55\u4fa1\u3088\u308a\u80de\u80da\u8154\u306e\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u306e\u95a2\u4fc2.jpg 782w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f312\u3000\u80da\u76e4\u80de\u5f62\u614b\u7684\u8a55\u4fa1\u3088\u308a\u80de\u80da\u8154\u306e\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u306e\u95a2\u4fc2-300x191.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2020\/06\/\u56f312\u3000\u80da\u76e4\u80de\u5f62\u614b\u7684\u8a55\u4fa1\u3088\u308a\u80de\u80da\u8154\u306e\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u306e\u95a2\u4fc2-768x489.jpg 768w\" sizes=\"auto, (max-width: 782px) 100vw, 782px\" \/><figcaption> <a><strong>\u56f312<\/strong><\/a><strong> &nbsp;\u80da\u76e4\u80de\u5f62\u614b\u7684\u8a55\u4fa1\u3088\u308a\u80de\u80da\u8154\u306e\u62e1\u5f35\u901f\u5ea6\u3068\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\u306e\u95a2\u4fc2<\/strong><br> Gardner\u6cd5\u3088\u308a\u80de\u80da\u8154\u306e\u5927\u304d\u3055\u304b\u3089\u5206\u985e\u3057\u305f\u5404Grade*\u3092\u898b\u308b\u3068\u3001\u521d\u671f\u80da\u76e4\u80de\u304b\u3089\u62e1\u5f35\u80da\u76e4\u80de\u307e\u3067\u3059\u3079\u3066\u306eStage\u3068\u3082\u9ad8\u3044\u983b\u5ea6\u306e\u69d8\u3005\u306a\u67d3\u8272\u4f53\u7570\u6570\u6027**\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u6210\u9577\u901f\u5ea6\u306e\u901f\u3044\u80da\u76e4\u80de\u306b\u306f\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\uff08\u6b63\u5e38\uff09\u306e\u78ba\u7387\u304c\u9ad8\u3044\u3002 ( grade 5\u20136 \u306e\u80da\u306f 49.2% )\u6210\u9577\u901f\u5ea6\u306e\u9045\u3044\u80da\u76e4\u80de\u306b\u306f\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\uff08euploidy\uff09\u306e\u78ba\u7387\u304c\u4f4e\u3044\u3002 ( grade 1\u20132 \u306e\u80da\u306f 37.5% )\u540c\u69d8\u306b\u3001\u80da\u76e4\u80de\u306eICM\u3068TE\u306e\u7d30\u80de\u6570\u3082\u591a\u304f\u5bc6\u3067\u3042\u308c\u3070\u3042\u308b\u7a0b\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\uff08euploidy\uff09\u306e\u78ba\u7387\u304c\u9ad8\u3044\u3002 <strong>10)<\/strong><br> * Gardner grading system \u306b\u3064\u3044\u3066\u3001\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad8\u7802\u306f inner cell mass (ICM) \u3068 trophectoderm (TE) \u306eA, B, C \u8a55\u4fa1\u306f<a>\uff62Grade\u300d<\/a>\u3068\u8868\u73fe\u3059\u308b\u3002degree of blastocyst expansion (score 1\u20136) \u306f\u300cStage\u300d\u3068\u8868\u73fe\u3059\u308b\u3002\u56f39\uff0c\u56f310\u306b\u53c2\u8003\u3002\u53c2\u8003\u6587\u732e10\uff09\u306b\u8ff0\u3079\u3089\u308c\u308b\uff62Grade\u300d\u3068\u306f\u9055\u3046\u8868\u73fe\u3067\u3042\u308b\u3002<br> **\u69d8\u3005\u306a\u67d3\u8272\u4f53\u7570\u6570\u6027:&nbsp; Monosomy\uff08\uff11\u500d\u4f53\uff09, Trisomy\uff08\uff13\u500d\u4f53<a>\uff09<\/a>, Double aneuploidy\uff08\uff12\u672c\u67d3\u8272\u4f53\u7570\u6570\u6027\uff09, Complex aneuploidy\uff08\uff13\u672c\u4ee5\u4e0a\u67d3\u8272\u4f53\u7570\u6570\u6027\uff09 <\/figcaption><\/figure>\n\n\n\n<h3><span id=\"i-10\"><a id=\"embryoscope\"><\/a>\u80da\u306e\u9078\u5225\u8981\u4ef6<\/span><\/h3>\n<p>\u67d3\u8272\u4f53\u6b63\u500d\u6570\u6027\uff08euploidy\uff09\u306e\u80da\u79fb\u690d\u306f\u6b63\u5e38\u306a\u598a\u5a20\u3001\u51fa\u751f\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3067\u3042\u308b\u3002<br \/>\u7740\u5e8a\u524d\u67d3\u8272\u4f53\u7570\u6570\u6027\u691c\u67fb\u306f\u3001Mosaicism\u306e\u554f\u984c\u306b\u3064\u3044\u3066\u8b70\u8ad6\u304c\u6b8b\u308b\u304c11\uff09\u30012018\u5e74\u30a2\u30e1\u30ea\u30ab\u751f\u6b96\u533b\u5b66\u4f1a\uff08ASRM\uff09\u306ecommittee opinion\u304cPGT-A\uff08 PGT-A : Preimplantation genetic testing for aneuploidy\uff09\u306b\u3064\u3044\u3066\u3001\u5358\u4e00\u80da\u79fb\u690d\u306b\u3088\u308b\u598a\u5a20\u7387\u3084\u751f\u7523\u7387\u3092\u5411\u4e0a\u3055\u305b\u3001\u591a\u80ce\u306e\u767a\u751f\u3092\u4f4e\u4e0b\u3055\u305b\u308b\uff1b38\uff5e41\u6b73\u306e\u9ad8\u9f62\u5973\u6027\u306b\u5bfe\u3057PGT-A\u306e\u6709\u7528\u6027\uff1b1\u4eba\u306e\u5b50\u3069\u3082\u3092\u7372\u5f97\u3059\u308b\u80da\u79fb\u690d\u56de\u6570\u3082\u5c11\u306a\u304f\u3001\u598a\u5a20\u307e\u3067\u306e\u671f\u9593\u3082\u77ed\u7e2e\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u300212\uff09\u53cd\u5fa9\u7740\u5e8a\u5931\u6557\u3068\u6d41\u7523\u306b\u3082\u305f\u3089\u3059\u5973\u6027\u306e\u8eab\u4f53\u7cbe\u795e\u7684\u8ca0\u62c5\u3092\u8efd\u6e1b\u3059\u308b\u70ba\u306b\u3001\u7740\u5e8a\u524d\u67d3\u8272\u4f53\u7570\u6570\u6027\u691c\u67fb(PGT-A)\u306f\uff11\uff10\u5e74\u4ee5\u4e0a\u304b\u3089\u6b27\u7c73\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u6d77\u5916\u3067\u306f86\uff05\u306e\u56fd\u3067PGT-A\u3092\u5b9f\u65bd\u53ef\u80fd\u3067\u3042\u308b\u304c\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u65e5\u672c\u3067\u306f\u502b\u7406\u7684\u554f\u984c\u3067\u81e8\u5e8a\u5fdc\u7528\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n<p>\u5206\u5272\u80da\u3001\u80da\u76e4\u80de\u306e\u5f62\u614b\u7684\u8a55\u4fa1\u306f\u3001\u598a\u5a20\u7387\u3092\u63a8\u6e2c\u3059\u308b\u305f\u3081\u306e\u7c21\u4fbf\u306a\u65b9\u6cd5\u3067\u3042\u308b\u304c\u3001\u5341\u5206\u3068\u306f\u8a00\u3048\u306a\u3044\u3002\u8fd1\u5e74\u3001<strong>\u53d7\u7cbe\u5375\u3001\u57f9\u990a\u5668\u5185\u306e\u5bc6\u5c01\u3055\u308c\u305f\u74b0\u5883\u3067\u9023\u7d9a\u7684\u306b\u80da\u3092\u9855\u5fae\u93e1\u4e0b\u306b\u64ae\u5f71\u3059\u308bTime-lapse cinematographic incubator\u304c\u3001\u958b\u767a\u30fb\u5c0e\u5165\u3055\u308c\u3001\u80da\u306e\u5f62\u614b\u5909\u5316\u3092\u3001\u7cbe\u7d30\u304b\u3064\u9023\u7d9a\u7684\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u5f93\u6765\u3001\u80da\u306e\u5f62\u614b\u8a55\u4fa1\u306e\u305f\u3081\u306b\u3001\u57f9\u990a\u5668\u306e\u4e2d\u304b\u3089\u4e00\u6642\u7684\u306b\u53d6\u308a\u51fa\u3055\u306a\u3051\u308c\u3070\u306a\u3089\u305a\u3001\u305d\u306e\u969b\u3001\u591a\u5c11\u306a\u308a\u80da\u5468\u56f2\u306e\u74b0\u5883\u5909\u5316\u304c\u8d77\u304d\u308b\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u4e0e\u3048\u308b\u30ea\u30b9\u30af\u304c\u3042\u3063\u305f\u3002Time-lapse cinematographic incubator\u306b\u304a\u3044\u3066\u306f\u305d\u306e\u30ea\u30b9\u30af\u3092\u306a\u304f\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u307e\u305f\u3001\u9023\u7d9a\u7684\u306a\u80da\u306e\u52d5\u614b\u89b3\u5bdf\u306b\u3088\u308a\u5375\u7d30\u80de\u8cea\u5185\u306e\u7570\u5e38\u3001\u524d\u6838\u6d88\u5931\u6642\u9593\uff0c\u5404\u5375\u5272\u6642\u9593\uff0c\u7570\u5e38\u5206\u5272\u306e\u6709\u7121\u306a\u3069\uff0c\u80da\u76e4\u80de\u306b\u81f3\u308b\u307e\u3067\u306e\u9014\u4e2d\u7d4c\u904e\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u5305\u62ec\u7684\u306b\u6d3b\u7528\u3057\u300113)14) 15)\u3088\u308a\u52b9\u7387\u7684\u306b\u67d3\u8272\u4f53\u7570\u5e38\u3092\u4e88\u6e2c\u3057\u79fb\u690d\u80da\u3092\u9078\u5225\u3059\u308b\u3053\u3068\u3067\u3001\u598a\u5a20\u7387\u3068\u751f\u7523\u7387\u306e\u5411\u4e0a\u3092\u671f\u5f85\u3067\u304d\u308b\u3002<a href=\"https:\/\/okawa-obgyn.com\/takasago\/beginner\/%e4%bd%93%e5%a4%96%e5%8f%97%e7%b2%be-ivf%e3%83%bb%e9%a1%95%e5%be%ae%e6%8e%88%e7%b2%be-icsi\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #ff0000;\">\u73fe\u5728\u3001\u5f53\u9662\u3067\u3082EmbryoScope time-lapse system \uff08Vitrolife\u793e \uff09\u3092\u5c0e\u5165\u3057\u3066\u3044\u308b\u3002<\/span><\/a><\/strong>\u4eca\u5f8c\u3001\u540c\u30b7\u30b9\u30c6\u30e0\u306e\u904b\u7528\u306b\u3088\u308b\u6210\u7e3e\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u3066\u3044\u304f\u3002<\/p>\n<p><span style=\"font-size: 12pt;\"><strong><span style=\"color: #666699;\">\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad9\u7802\uff08\u5927\u5dddART)\u539f\u8457\u00a0 \u3000\u3000\u3000<\/span><\/strong><\/span><span style=\"font-size: 12pt;\"><strong><span style=\"color: #666699;\"><span style=\"color: #008000;\"><a style=\"color: #008000;\" href=\"https:\/\/okawa-obgyn.com\/hosp\/about\/message\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u6587\u8cac \u540d\u8a89\u9662\u9577 \u5927\u5ddd\u6b23\u6804<\/a><\/span><\/span><\/strong><\/span><br \/><br \/><span style=\"font-size: 14pt;\"><a href=\"https:\/\/okawa-obgyn.com\/takasago\/beginner\/%e8%83%9a%e5%87%8d%e7%b5%90%e4%bf%9d%e5%ad%98%e3%83%bb%e8%83%9a%e7%9b%a4%e8%83%9e%e7%a7%bb%e6%a4%8d\/%e7%9d%80%e5%ba%8a%e3%81%97%e3%82%84%e3%81%99%e3%81%84%e3%81%ae%e3%82%b5%e3%83%9d%e3%83%bc%e3%83%88\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #ff6600;\">EMBRYOSCOPE\u2013Time Lapse System \u52d5\u753b Click!<\/span><\/a><br \/><br \/><strong>\u53c2\u8003\u6587\u732e<\/strong><\/span><\/p>\n<p>1 \u5927\u5ddd\u5f66\u5b8f, \u5927\u5ddd\u6b23\u6804, \u6709\u6751\u8ce2\u4e00\u90ce, \u4ed6\uff1a\u5973\u6027\u5e74\u9f62\u306b\u3088\u308b\u598a\u5b55\u529b\u306e\u5909. \u30a2\u30eb\u30e1\u30a4\u30c0\u533b\u5831, 2019; Vol. 44, No. 1, 2-10<\/p>\n<p>2 \u5927\u5ddd\u6b23\u6804, \u6709\u6751\u8ce2\u4e00\u90ce, \u5927\u5ddd\u5f66\u5b8f, \u4ed6\uff1a\u5375\u5b50\u306e\u751f\u6daf\u767a\u80b2\u3068FSH, AMH, AFC\u306e\u5f79\u5272. \u30a2\u30eb\u30e1\u30a4\u30c0\u533b\u5831, 2019; Vol. 44, No. 1, 11-19<\/p>\n<p>3 \u77f3\u539f \u7406, \u7247\u6850\u7531\u8d77\u5b50, \u6851\u539f \u7ae0: \u5e73\u621030\u5e74\u5ea6\u502b\u7406\u59d4\u54e1\u4f1a\u3000\u767b\u9332\u30fb\u8abf\u67fb\u5c0f\u59d4\u54e1\u4f1a\u5831\u544a\uff082017\u5e74\u5206\u306e\u4f53\u5916\u53d7\u7cbe\u30fb\u80da\u79fb\u690d\u7b49\u306e\u81e8\u5e8a\u5b9f\u65bd\u6210\u7e3e\u304a\u3088\u30732019\u5e747\u6708\u306b\u304a\u3051\u308b\u767b\u9332\u65bd\u8a2d\u540d\uff09. \u65e5\u7523\u5a66\u8a8c, 2019\u5e7411\u6708, 71\u5dfb11\u53f7, 2509 \u2013 2573<\/p>\n<p>4 Gaurav Majumdar, Abha Majumdar, Ishwar C. Verma, et al: Relationship Between Morphology, Euploidy and Implantation Potential of Cleavage and Blastocyst Stage Embryos. J Hum Reprod Sciv.10(1); 2017 Apr-Jun; 10(2): 142\u2013150 <br \/>5 Toshio Hamatani, Yasunori Yoshimura,: \u751f\u6b96\u88dc\u52a9\u533b\u7642\u6280\u8853\uff08Assisted Reproductive Technology\uff1aART\uff09,\u65e5\u7523\u5a66\u8a8c60\u5dfb12\u53f7, 2008\u5e7412\u6708, 495 \u2013 504<\/p>\n<p>6 \u8c4a\u5ca1\u3084\u3088\u3044\u3001\u85e4\u68ee\u4fca\u5f66\uff1a\u7740\u5e8a\u524d\u306e\u80da\u306b\u304a\u3044\u3066\u3001\u6c7a\u307e\u308a\u304b\u3051\u305f\u7d30\u80de\u306e\u904b\u547d\u304c\u7d30\u80de\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u5909\u66f4\u3055\u308c\u308b\u69d8\u5b50\u3092\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308a\u89b3\u5bdf\u3059\u308b\u3053\u3068\u306b\u6210\u529f\uff0e\u57fa\u790e\u751f\u7269\u5b66\u7814\u7a76\u6240\u30012016.02.16\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/p>\n<p>7 Yayoi Toyooka, Sanae Oka, Toshihiko Fujimori: Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes. Developmental Biology\u3001March 2016, Volume 411, Issue 1, 1, 50-60<br \/>8 Ismael Galve-Roperh, ValerioChiurchi\u00f9, JavierD\u00edaz-Alonso, et al: Cannabinoid receptor signaling in progenitor\/stem cell proliferation and differentiation. Progress in Lipid Research, October 2013, Volume 52, Issue 4, 633-650<\/p>\n<p>9 Jason M. Franasiak, Eric J. Forman, Kathleen H. Hong, et al: The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertility and Sterility, March 2014 ; Vol. 101, No. 3, 0015-0282<\/p>\n<p>10 Samer Alfarawati, Elpida Fragouli, Pere Colls, et al: The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertility and Sterility. February 2011; Vol. 95, No. 2, 520\u2013524<br \/>11 Mandy Katz-Jaffe: Reduce your mosaic embryos by optimising your laboratory<br \/>conditions. Eshre 34th Annual Meeting, Barcelona, Spain, July 2018<br \/>12 AlanPenzias, KristinBendikson, SamanthaButts, et al: The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion. Fertility and Sterility. March 2018; Vol. 109, No. 3, 429-436<\/p>\n<p>13 H. Nadir Ciray, Alison Campbell2, Inge Errebo Agerholm, et al: Proposed guidelines on the nomenclature and annotation ofdynamic human embryo monitoring by a time-lapse user group. Human Reproduction, 2014, Vol.29, No.12, 2650\u20132660<\/p>\n<p>14 E. Rocafort, M. Enciso, A. Leza, et al: Euploid embryos selected by an automated time-lapse system have superior SET outcomes than selected solely by conventional morphology assessment. Journal of Assisted Reproduction and Genetics, 2018, 35:1573\u20131583<\/p>\n<p>15 Shiao-Hsuan Yang a, Cheng-Hsuan Wu a, Yu-Ching Chen: Effect of morphokinetics and morphological dynamics of cleavage stage on embryo developmental potential: A time-lapse study. Taiwanese Journal of Obstetrics &amp; Gynecology. 2018, 57, 76-82<\/p>\n<h2><span id=\"i-11\">\u82f1\u6587\u7dcf\u62ec<\/span><\/h2>\n<p><span style=\"font-size: 14pt;\">The Current Trends in In Vitro Fertilization: A Focus on the Relationship between Embryo Morphologic Evaluation and Pregnancy Outcome (Review)<\/span><\/p>\n<p>SUMMARY<\/p>\n<p>In vitro fertilization (IVF; ART: Assisted Reproductive Technology) is highly effective for infertility. In Japan in 2017, 448,210 ART cycles (most worldwide), 251,279 embryo transfers, 79,194 pregnancies, and 56,617 live births occurred. Every class of 40 schoolchildren comprised 2.4 ART-produced babies.<br \/>In the last two decades, some current trends are recognized in Japan ART. Per the 2017 data book of JSOG (Japan Society of Obstetrics and Gynecology), there are 42% of patients undergoing ART were aged &gt;40 years; frozen-thawed blastocyst transfer was performed in &gt;80% , with a higher single-embryo transfer rate (&gt;90% when aged &lt;35 years and &gt;80% when aged &lt;43 years) , lowering the multiple pregnancy rate down to 3%. Most ART centers prefer transferring blastocysts rather than cleavages to achieve higher pregnancy rates. On the other hand, mature oocyte cryopreservation, donor egg IVF, and preimplantation genetic testing for aneuploidies (PGT-A) remain restricted in Japan due to conservative ethical considerations, laws, and regulations.<br \/>A study included patients who received frozen-thawed single cleavage transfer (n=428) and blastocyst transfer (n=654) at our Okawa ART Center was performed between Jan 2014 and Dec 2018. The Day3 cleavages and Day5-6 blastocysts were morphologically evaluated per Veeck and Gardner grading system respectively. The pregnancy rates of frozen-thawed single cleavage transfer were 16.7% in 7-cell (n=42), 31.8% in 8-cell(n=267), 22.9% in 9-cell (n=48) and 22.5% in \u226510-cell (n=71). <br \/>The clinic pregnancy rates of frozen-thawed single blastocyst transfer, per the blastocoel expansion stage, were 35.5% at stage 3 (n=110), 47.1% at stage 4 (n=520) and 58.3% at stage 5 (n=24). The pregnancy rates at stage 4 and 5 were significantly higher than that at stage 3. (Chi-square test, p&lt;0.05, p&lt;0.05, respectively). The overall pregnancy rate for 654 cycles was 45.6%. <br \/>Meanwhile, per the ICM and TE cells grading, the pregnancy rates were 55.0% in grade AA (n=289), 38.9% in grade AB and BA (n=252), 35.7% in grade BB (n=112) and 16.7% in grades lower than BB (n=6). The pregnancy rate of Grade AA was significantly higher than that of Grade AB, BA (Chi-square test: \u03c72=14.04, p &lt; 0.001) and significantly higher than that of Grade BB (Chi-square test: \u03c72=12.03, p &lt; 0.001).<br \/>Our study demonstrated a reliable but indefinite relationship between the embryo morphologic evaluation and Pregnancy Outcome. A combination method based on traditional morphologic evaluation, morphokinetic evaluation using Time-lapse cinematographic incubator (e.g., Embryoscope, Vitrolife\u00ae), and PGT-A (preimplantation genetic testing for aneuploidies) should be proposed in selected cases for better pregnancy outcome.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"\/takasago\/images\/2024\/03\/91c32592-4a25-4d0a-9301-e76be91def77-1024x1024.jpg\" alt=\"\" class=\"wp-image-1966\" srcset=\"https:\/\/okawa-obgyn.com\/takasago\/images\/2024\/03\/91c32592-4a25-4d0a-9301-e76be91def77.jpg 1024w, https:\/\/okawa-obgyn.com\/takasago\/images\/2024\/03\/91c32592-4a25-4d0a-9301-e76be91def77-300x300.jpg 300w, https:\/\/okawa-obgyn.com\/takasago\/images\/2024\/03\/91c32592-4a25-4d0a-9301-e76be91def77-150x150.jpg 150w, https:\/\/okawa-obgyn.com\/takasago\/images\/2024\/03\/91c32592-4a25-4d0a-9301-e76be91def77-768x768.jpg 768w\" 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-->","protected":false},"excerpt":{"rendered":"<p>\u2460\u5973\u6027\u5e74\u9f62\u306b\u3088\u308b\u598a\u5b55\u529b\u306e\u5909\u5316\u3000\uff08\u5375\u5de3\u4e88\u5099\u80fd\u2460\uff09\u2461\u5375\u5b50\u306e\u751f\u6daf\u767a\u80b2\u3068FSH, AMH, AFC \u306e\u5f79\u5272\uff08\u5375\u5de3\u4e88\u5099\u80fd\u2461\uff09\u2462\u4f53\u5916\u53d7\u7cbe\u306e\u52d5\u5411\uff5e\u80da\u306e\u9078\u5225\u3068\u79fb\u690d\u306e\u598a\u5a20\u7387\uff08\u5927\u5dddART\u306e\u598a\u5a20\u7387\uff09\u5927\u5ddd\u7523\u5a66\u4eba\u79d1\u30fb\u9ad9\u7802\uff08\u5927\u5dddART)\u539f\u8457\u00a0 \u3000\u3000 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